Products Allopurinol is in the form of tablets trade (Zyloric, generic). It is approved in many countries since the year 1966. Allopurinol is also combined with the URAT1 inhibitor lesinurad. Structure and properties Allopurinol (C5H4N4O, Mr = 136.1 g/mol) exists as a white powder that is very sparingly soluble in water. It is a derivative … Allopurinol (Zyloprim)
In allosteric inhibition, or noncompetitive inhibition, inhibitors bind to the allosteric center of an enzyme, thereby reducing its activity. The binding results in a conformational change that partially or completely blocks the function of the enzyme. Allosteric inhibition is being considered for the treatment of cancer. What is allosteric inhibition? In allosteric inhibition, inhibitors bind … Allosteric Inhibition (Non-Competitive Inhibition): Function, Role & Diseases
Products Probenecid is commercially available in tablet form (Santuril). Santuril has been approved in many countries since 2005. Structure and properties Probenecid (C13H19NO4S, Mr = 285.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Probenecid (ATC M04AB01) inhibits tubular reabsorption of uric acid and secretion of organic anions. It thus … Probenecid
Aldehyde oxidase represents an enzyme that degrades aldehydes in vertebrates. It is found in various tissues of mammals and humans. The exact function of aldehyde oxidase is not yet known. What is aldehyde oxidase? Aldehyde oxidase (AOX1) helps in the enzymatic breakdown of aldehydes in the body. However, it has also been found to break … Aldehyde Oxidase: Function & Diseases
Uric acid is the end product of purine metabolism. Purine is necessary for the construction of ribonucleic acid (RNA) as well as deoxyribonucleic acid (DNA), which are found in the body’s cells and carry genetic information. What is uric acid? Purine is ingested with food (e.g., meat) and is therefore nonessential. Uric acid is formed … Uric Acid: Function & Diseases
Products Chlortalidone is commercially available in tablet form (combination products). It has been approved in many countries since 1967. This article refers to the monopreparations. Hygroton (Novartis) was discontinued in many countries in 2014. Structure and properties Chlortalidone (C14H11ClN2O4S, Mr = 338.77 g/mol) is a racemate. It exists as a white to yellowish white powder … Chlortalidone
The basis of all life is water – “from heaven it comes, to heaven it rises…”- already Goethe wrote in his wonderful poem about water. Water is habitat for an infinite number of plants and animals. In order for it to be available for biodiversity and sustainable use in the long term, it is essential … Water: Intolerance & Allergy
In the salvage pathway, a new biomolecule is synthesized from the degradation products of a biomolecule. The salvage pathway is also known as the salvage pathway and is, in a sense, a form of recycling within metabolism. What is the salvage pathway? Salvage pathway refers firstly to the general form of this recycling within metabolism … Salvage Pathway: Structure, Function & Diseases
Urine is the body’s way of getting rid of excess substances such as metabolic waste products, medications and toxins. Urine is also part of a regulatory mechanism that keeps fluid and electrolytes in balance. Its analysis can provide clues to various disorders. Composition of urine Urine is 95% water, in addition to containing metabolic (end) … When is Urinalysis Necessary?
Purines are substances in food. They are a component of every cell and are necessary for the genetic material and the construction of new cells. When purines are broken down from food, uric acid is formed. In some people, this cannot be excreted in sufficient quantities. This results in excessive uric acid levels in the … What are Purines?
Peas are one of the most popular legumes and are further processed either fresh or dried. Sweet peas are the only legume that can also be eaten raw. Green peas are mainly frozen or canned, with frozen peas becoming increasingly popular as they still contain all the vitamins. Here’s what you should know about the … Pea: Intolerance & Allergy
Synonym: joint inflammation English: arthritis Arthritis is an inflammation of the joints that can occur in connection with various diseases. Therefore, a distinction is made between different forms of arthritis, see Causes. Arthritis manifests itself through the typical symptoms of inflammation: The joint is reddened, swollen, overheated and painful. If only a single joint is … Arthritis
