How Valsartan works Valsartan blocks the receptors (docking sites) of the hormone angiotensin-II – more precisely, the AT-1 receptors, which means that the hormone can no longer exert its effect. This prevents a rise in blood pressure and thus relieves the heart and kidneys. The salt and water balance in the human body is regulated … Valsartan: Effect, Applications, Side Effects
Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans
Products Valsartan is commercially available in the form of film-coated tablets and has been approved since 1996 (Diovan, generic). The active ingredient is also combined fixed with other agents: Hydrochlorothiazide (co-Diovan, Exforge HCT with amlodipine, generics). Amlodipine (Exforge, generic). Sacubitril (Entresto) Valsartan scandal: in July 2018, numerous generic drugs had to be recalled from the … Valsartan
Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)
Products Nebivolol is commercially available in tablet form as a monopreparation (Nebilet, generic, USA: Bystolic) and in combination with hydrochlorothiazide (Nebilet plus). The active ingredient has been approved in many countries since 1998. A fixed combination with valsartan is also available in some countries (Byvalson). Structure and properties Nebivolol (C22H25F2NO4, Mr = 405.4 g/mol) has … Nebivolol
Definition Drugs today usually contain a defined active pharmaceutical ingredient. However, numerous drugs with two or more active substances also exist. These are called combination drugs or fixed combinations. For example, Aspirin C contains both acetylsalicylic acid and vitamin C. Many blood pressure medications are combination preparations, for example perindopril + indapamide or candesartan + … Combination Products
Products Amlodipine is commercially available in tablet form (Norvasc, generic). It has been approved in many countries since 1990. Amlodipine is also combined fixed with the following agents: Aliskiren, atorvastatin, perindopril, telmisartan, valsartan, olmesartan, hydrochlorothiazide, and indapamide. Structure and properties Amlodipine (C20H25ClN2O5, Mr = 408.9 g/mol) has a chiral center and is a racemate. It … Amlodipine (Norvasc)
Hydrochlorothiazide and valsartan Definition CoDiovan® is a drug that lowers blood pressure. Effect CoDiovan® is used when one of its active ingredients does not lower blood pressure sufficiently, either due to lack of potency or due to side effects that are too strong at low doses. As these 2 substances intervene in different ways in … CoDiovan
Dosage CoDiovan® is swallowed as a tablet once a day. These tablets usually contain 80 mg, 160 mg or 320 mg valsartan and 12.5 or 25 mg hydrochlorothiazide. Depending on the reason for the intake and the severity of the symptoms, the required dose may vary, but higher doses than 320mg/25mg are not recommended. Side … Dosage | CoDiovan
Symptoms High blood pressure is often asymptomatic, meaning that no symptoms occur. Nonspecific symptoms such as headache, bleeding in the eye, nosebleeds, and dizziness are observed. In advanced disease, various organs such as the vessels, retina, heart, brain and kidney are affected. Hypertension is a known and important risk factor for atherosclerosis, dementia, cardiovascular diseases … Hypertension
General information Diovan® contains the active ingredient valsartan, which is used to treat high blood pressure and mild to moderate heart failure. Diovan® belongs to the drug group of angiotensin-1 antagonists. They are used when ACE inhibitors do not work or are unsuitable. The drug is available only on prescription and the medication should be … Diovan
Contraindications If one or more of the following points apply to you, you should not take Diovan®! Since there are no reports of Diovan® use in children and adolescents under 18 years of age, it is not recommended. Valsartan should not be taken during pregnancy as experiments on mice showed damage to newborns and even … Contraindications | Diovan
