Anti-GBM (glomerular basement membrane) disease, formerly Goodpasture’s syndrome
Pathogenesis (disease development).
The disease is caused by formed autoantibodies against the basement membrane of blood vessels. The blood vessels of the renal glomeruli and alveoli (pulmonary alveoli) are particularly affected.
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome (CSS)
Pathogenesis (disease etiology).
The etiology (causes) of eosinophilic granulomatosis with polyangiitis (EGPA) is unknown. For more information, see the disease of the same name.
Etiology (Causes)
Disease-related causes
Medications
- Montelukast is discussed as a triggering agent
Granulomatosis with polyangiitis, formerly Wegener’s granulomatosis
Pathogenesis (disease etiology).
The etiology of granulomatosis with polyangiitis (GPA) remains largely unexplained.For more information, see the disease of the same name.
Isolated leukocytoclastic skin vasculitis
Pathogenesis (disease development).
Isolated leukocytoclastic cutaneous vasculitis is a form of vasculitis in which only blood vessels of the skin are affected. Histologic examination may reveal destroyed leukocytes (white blood cells), hence the name leukocytoclastic.
In a large number of cases, no trigger of isolated leukocytoclastic house vasculitis can be found. A dysfunction of the immune system is suspected.
Etiology (Causes)
Disease-related causes.
Infectious and parasitic diseases (A00-B99).
- Infections, unspecified
Neoplasms – tumor diseases (C00-D48).
- Tumor disease, unspecified
Medication
- Antibiotics – drugs that are used against bacterial infections.
- Antirheumatics – drugs that are used against rheumatic diseases.
Kawasaki syndrome (MPA)
Pathogenesis (disease etiology).
The etiology of Kawasaki syndrome is unknown. Genetic factors are suspected.
Microscopic polyangiitis (MPA)
Pathogenesis (disease etiology).
The etiology of microscopic polyangiitis (MPA) remains unclear. For further discussion, see the disease of the same name.
Polyarteritis nodosa (PAN; panarteritis nodosa)
Pathogenesis (disease development).
As with almost all autoimmune diseases, the etiology is unknown. However, 30% of cases of polyarteritis nodosa are associated with chronic hepatitis C (predominantly genotype 2) or hepatitis B.
Schönlein-Henoch purpura
Pathogenesis (disease development).
It is likely that Schönlein-Henoch purpura is a genetic-based immunopathologic reaction caused by various triggers (infections, drugs).For more information, see the disease of the same name.
