Subclinical Inflammation

Subclinical Inflammation: Medical History

Medical history (history of illness) represents an important component in the diagnosis of subclinical inflammation (silent inflammation). Family history Are there any diseases in your family that are common? Social history What is your profession? Are you exposed to harmful working substances in your profession? Are you unemployed? Is there any evidence of psychosocial stress … Subclinical Inflammation: Medical History

Subclinical Inflammation: Complications

The following are the most important diseases or complications that can be caused by subclinical inflammation (silent inflammation): Respiratory system (J00-J99) Chronic obstructive pulmonary disease (COPD). Eyes and eye appendages (H00-H59). Macular degeneration – degenerative disease of the macula lutea (yellow spot of the retina/retinal). Endocrine, nutritional and metabolic diseases (E00-E90). Obesity Diabetes mellitus type … Subclinical Inflammation: Complications

Subclinical Inflammation: Examination

Regardless of the fact that subclinical inflammation does not cause immediate symptoms, please note that subclinical inflammation itself may in turn be the cause of symptoms of the secondary diseases it causes. General physical examination – including blood pressure, pulse, body weight, height; furthermore: Inspection (viewing). Skin, mucous membranes and sclerae (white part of the … Subclinical Inflammation: Examination

Subclinical Inflammation: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Inflammatory parameters-CRP (C-reactive protein)/hs-CRP (high-sensitivity C-reactive protein). Laboratory parameters 2nd order – depending on the results of the history, physical examination, etc. – for differential diagnostic clarification. Tumor necrosis factor (TNF-alpha) (proinflammatory). Interleukin-6 (IL-6) (proinflammatory) Lipopolysaccharide (LPS); sample collection: sterile, fasting (> 4 h after the last … Subclinical Inflammation: Test and Diagnosis

Subclinical Inflammation: Prevention

To prevent subclinical inflammation (silent inflammation), attention must be paid to reducing individual risk factors. Behavioral risk factors Diet Increased intake of saturated fatty acis (SFA). Increased intake of foods with high glycemic index → increase in NF-κB activation and NF-κB binding in mononuclear cells. Consumption of contaminated foods (e.g., pesticides, heavy metals, etc.). Consumption … Subclinical Inflammation: Prevention

Subclinical Inflammation: Causes

Pathogenesis (disease development) (Subclinical) inflammation (“silent inflammation”) is an expression of an innate (nonspecific) immune response of the organism. Endogenous and/or exogenous stimuli (see etiology/causes below) that compromise physiologic processes are the cause of inflammation. In the course of metabolization, e.g. conjugation of polar and hydrophilic substances (e.g. glucuronization, methylation, etc.), molecules are consumed for … Subclinical Inflammation: Causes