Products Astemizole was commercially available in tablet and suspension form (Hismanal). It has been withdrawn from the market in many countries because of potential adverse effects and is no longer available (see below). It may well be replaced by other, better-tolerated antihistamines, such as cetirizine, loratadine, and fexofenadine. Structure and properties Astemizole (C28H31FN4O, Mr = … Astemizole
Products Diphenylpyralin was included in Arbid drops in combination with buphenin until late 2011. Arbid had been approved in many countries since 1965. Structure and properties Diphenylpyralin (C19H23NO, Mr = 281.4 g/mol) has a structure comparable to other antihistamines. It is present in drugs as diphenylpyraline hydrochloride. Effects Diphenylpyralin (ATC R06AA07) is antihistamine and antisecretory. … Diphenylpyralin
Effects Antihistamine eye drops have antihistamine and antiallergic properties. They are more or less selective antagonists of histamine at the H1 receptor, abolish histamine effects and thus relieve symptoms such as itching, redness, swelling, and tearing. Compared with oral antihistamines, the effect occurs after only a few minutes and lasts up to 12 hours. Many … Antihistamine Eye Drops
Effects Antihistamine nasal sprays have antihistamine and antiallergic properties. They are antagonists of histamine at the H1 receptor, reversing histamine effects and thus relieving symptoms such as sneezing, itching, and runny nose. Azelastine is also mast cell stabilizing, which is considered a therapeutic advantage. Glucocorticoid nasal sprays are more effective than antihistamine nasal sprays, but … Antihistamine Nasal Sprays
Products Mepyramine is commercially available as a gel, an external solution, and a spray. It is found exclusively in combination products, for example, Stilex and Parapic. Structure and properties Mepyramine (C17H23N3O, Mr = 285.38 g/mol) is present in drugs as mepyramine maleate, a white to slightly yellowish powder that is very soluble in water. It … Mepyramine
Products Fexofenadine is commercially available in tablet form (Telfast, Telfastin Allergo, generic). It was approved in many countries in 1997 and has been available without a doctor’s prescription since 2010. Telfastin Allergo 120 for self-medication went on sale in February 2011. Fexofenadine is the successor product to terfenadine (Teldane), which had to be withdrawn from … Fexofenadine
Products Buclizine is no longer commercially available in many countries. It was formerly available in Migraleve with codeine and acetaminophen and Longifene. However, there are many antihistamines on the market that can be used as substitutes. Structure and properties Buclizine (C28H33ClN2, Mr = 433.0 g/mol) is a piperidine derivative. Effects Buclizine (ATC R06AE01 is antiallergic, … Buclizine
Products Epinastine is commercially available in the form of eye drops (Relestat). It has been approved in many countries since 2004. Structure and properties Epinastine (C16H15N3, Mr = 249.31 g/mol) is present in drugs as epinastine hydrochloride. It is an azepine and imidazole derivative. Effects Epinastine (ATC S01GX10) has antihistamine, antiallergic, and mast cell stabilizing … Epinastine
Products Bamipin is commercially available in Germany and Austria as a gel for topical use (Soventol). The drug is not registered in many countries. Structure and properties Bamipin (C19H24N2, Mr = 280.4 g/mol) is a piperidineamine derivative. In the drug product, it is present as racemate and bamipine lactate. Effects Bamipin (ATC D04AA15) has antihistamine, … Bamipin
Products Drug product containing acrivastine is no longer available in many countries. Semprex capsules are out of trade. Structure and properties Acrivastine (C22H24N2O2, Mr = 348.44 g/mol) is a derivative of the antihistamine triprolidine (not commercially available). It exists as an odorless, white, crystalline powder that is somewhat sparse in water. Acrivastine belongs to the … Acrivastin
Introduction Fenistil® Gel is a drug in the form of a transparent gel, which is produced by the pharmaceutical company Novartis. It is used for insect bites, minor burns or sunburn. It is not subject to prescription and can therefore be purchased without a prescription. Fenistil® Gel contains the active ingredient dimetinden, which has an … Fenistil® Gel
Active ingredient and effect of Fenistil® Gel The active ingredient of Fenistil® gel is called Dimetinden. It is an H1-receptor antagonist. This means that dimetinden binds to the H1 receptors and thus these binding sites are no longer accessible to histamine. If histamine can no longer bind to the receptors, the H1 receptors are not … Active ingredient and effect of Fenistil® Gel | Fenistil® Gel
