Products Oxiconazole was commercially available in the form of vaginal tablets (Oceral). It was approved in many countries since 1983. It was discontinued in 2017. Structure and properties Oxiconazole (C18H13Cl4N3O, Mr = 429.1 g/mol) is present in drugs as oxiconazole nitrate. It is an imidazole derivative. Effects Oxiconazole (ATC D01AC11, ATC G01AF17) has antifungal properties … Oxiconazole
Products Clotrimazole is commercially available as creams, creams, ointments, sprays, vaginal tablets, and vaginal creams alone or in combination with other active ingredients (e.g., Canesten, Gyno-Canesten, Imacort, Imazol, Triderm). It has been approved in many countries since 1973. Structure and properties Clotrimazole (C22H17ClN2, Mr = 344.8 g/mol) is a chlorinated phenylmethylimidazole derivative. It exists as … Clotrimazole
Products Ketoconazole has been approved in many countries since 1981 and is now only commercially available as a shampoo and as a cream for external treatment (Nizoral, generics). Nizoral tablets were taken off the market in 2012 due to declining demand. This article refers to external use. Structure and properties Ketoconazole (C26H28Cl2N4O4, Mr = 531.4 … Ketoconazole
Products Isavuconazonium sulfate is commercially available as a powder for a concentrate for the preparation of an infusion solution and in capsule form (Cresemba). It was approved in the US and EU in 2015 and in many countries in 2017. Structure and properties Isavuconazonium sulfate (C35H35F2N8O5S+ – HSO4– Mr = 814.8 g/mol) is a prodrug … Isavuconazonium Sulfate
Products Isoconazole is commercially available as a cream (Travogen, Travocort + diflucortolone valerate). It has been approved in many countries since 1980. The ovules are out of commerce. Structure and properties Isoconazole (C18H14Cl4N2O, Mr = 416.1 g/mol) is present in drugs as a racemate and as isoconazole nitrate, a white powder that is very sparingly … Isoconazole
Products Tioconazole is no longer available in many countries. Trosyd is out of commerce. Structure and properties Tioconazole (C16H13Cl3N2OS, Mr = 387.7 g/mol) Effects Tioconazole (ATC D01AC07, ATC G01AF08) is antifungal. Indications Fungal infections
Products Econazole is commercially available as a cream, powder, pump spray, vaginal cream, and vaginal suppository (Pevaryl, Gyno-Pevaryl, Pevisone + triamcinolone acetonide). The active ingredient has been approved in many countries since 1974. Structure and properties The imidazole derivative econazole (C18H15Cl3N2O, Mr = 381.7 g/mol) is a white powder that is practically insoluble in water. … Econazole
Products Voriconazole is commercially available as film-coated tablets, powder for the preparation of an infusion solution, and powder for the preparation of a suspension (Vfend, generics). It has been approved in many countries since 2002. Structure and properties Voriconazole (C16H14F3N5O, Mr = 349.3 g/mol) exists as a white powder that is very sparingly soluble in … Voriconazole
Products Sertaconazole is commercially available as a cream (Zalain). The drug is not available in many countries. Structure and properties Sertaconazole (C20H15Cl3N2OS, Mr = 437.8 g/mol) is present in drugs as sertaconazole nitrate, a white crystalline powder that is practically insoluble in water. Effects Sertaconazole (ATC D01AC14) is antifungal Indications Fungal skin infections
Products Miconazole is available as a cream, miconazole mouth gel and shampoo, and commercially (e.g., Daktarin). It has been approved in many countries since 1972. This article refers to external therapy. See also under miconazole mouth gel and miconazole for nail fungus. The nail tincture for nail fungus treatment is no longer marketed in many … Miconazole
Products Miconazole was commercially available for the treatment of nail fungus as a tincture (Daktarin). The drug was approved in many countries since 1981. It was discontinued from distribution in 2020. Structure and properties Miconazole (C18H14Cl4N2O , Mr = 416.13 g/mol) is an imidazole derivative. It is not present in the tincture as the salt … Miconazole against Nail Fungus
Products Fenticonazole is no longer on the market in many countries (Mycodermil Crème, Gyno-Mycodermil, Crème). Structure and properties Fenticonazole (C24H20Cl2N2OS, Mr = 455.4 g/mol) is present in drugs as fenticonazole nitrate, a white crystalline powder that is practically insoluble in water. It is a racemate. Effects Fenticonazole (ATC D01AC12, ATC G01AF12) has antifungal properties; see … Fenticonazole