Medical history (history of illness) represents an important component in the diagnosis of aplastic anemia. Family history Social history What is your occupation? Are you exposed to harmful working substances in your profession? Current medical history/systemic medical history (somatic and psychological complaints). Have you noticed an increased bleeding tendency such as increased bruising, gum bleeding, … Aplastic Anemia: Medical History
Blood, blood-forming organs-immune system (D50-D90). Amegakaryocytic thrombocytopenia – genetic disorder with autosomal dominant inheritance resulting in thrombocytopenia (abnormal reduction in platelets/platelets). Bleeding anemia, acute (source of bleeding: mainly genital or gastrointestinal/gastrointestinal tract). Iron deficiency anemia (anemia due to iron deficiency). Inflammatory anemia Elliptocytosis – group of rare defects of the membrane skeleton of erythrocytes (red … Aplastic Anemia: Or something else? Differential Diagnosis
The following are the most important diseases or complications that may be contributed to by aplastic anemia: Infectious and parasitic diseases (A00-B99). Infections of all kinds due to weakened immune defenses. Blood, blood-forming organs – immune system (D50-D90). Bleeding due to a reduction in platelets (thrombocytes); possible in all body tissues. Neoplasms (C00-D48) Acute myeloid … Aplastic Anemia: Complications
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes and sclerae ( white part of the eye) [increased hematoma formation (bruising)]. Abdomen (abdomen) Shape of the abdomen? Skin color? Skin texture? Efflorescences (skin changes)? Pulsations? … Aplastic Anemia: Examination
The following symptoms and complaints may indicate aplastic anemia: Increased bleeding tendency, manifested by increased hematoma formation (bruising), bleeding gums, or prolongation of menstrual periods Fatigue General weakness Shortness of breath Ringing in the ears Infections (occur overall rather rarely as the first symptom).
Nose on the phone with Pia Radiatio (radiation therapy) and how is she doing Pathogenesis (disease development) In aplastic anemia, an autoimmune reaction (pathological reaction of the immune system towards the body’s own tissue) towards the bone marrow occurs, among other things, due to infections (<5% of cases) and drugs/toxins (<10%). The bone marrow is … Aplastic Anemia: Causes
General measures Observance of the general hygiene measures! Nicotine restriction (refrain from tobacco use). Alcohol restriction (abstaining from alcohol) Aim for normal weight!Determination of BMI (body mass index, body mass index) or body composition using electrical impedance analysis. Fall below the BMI lower limit (from the age of 45: 22; from the age of 55: … Aplastic Anemia: Therapy
Therapeutic target Restoration of bone marrow function Therapy recommendations First-line method: allogeneic stem cell transplantation (in which blood stem cells are transferred from a donor to a recipient, i.e., donor and recipient are not the same person in this case); however, it depends on the presence of an HLA-identical donor. Immunosuppressants, these are indicated for: … Aplastic Anemia: Drug Therapy
Mandatory medical device diagnostics. Abdominal ultrasonography (ultrasound examination of abdominal organs) with a question about splenomegaly (measurement of the spleen). Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics and obligatory medical device diagnostics – for differential diagnostic clarification. Computed tomography (CT) of the abdomen (abdominal CT). Magnetic … Aplastic Anemia: Diagnostic Tests
To prevent aplastic anemia, attention must be paid to reducing individual risk factors. Environmental exposure – Intoxications (poisonings). Arsenic Benzene Bismuth Gold Mercury
