The most important diseases or complications that can be caused by sialadenitis (salivary gland inflammation) are:
Eyes and eye appendages (H00-H59).
- Inflammation of the eyes [parotitis epidemica]
- Dacryoadenitis (inflammation of the lacrimal glands) [parotitis epidemica]
- Keratoconjunctivitis sicca (“dry eyes”) [Sjögren’s or Sicca syndrome]
Certain conditions originating in the perinatal period (P00-P96).
- Sialadenal fetopathy (disease of the fetus) [prenatal cytomegalovirus disease].
Blood, blood-forming organs – immune system (D50-D90).
- Anemia (anemia) [parotitis epidemica/mumps]
- Werlhof’s disease (thrombocytopenic purpura; form of idiopathic thrombocytopenic purpura (ITP)) [Parotitis epidemica]
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Thyroiditis (inflammation of the thyroid gland) [parotitis epidemica].
Skin and subcutaneous tissue (L00-L99)
- Extraoral fistulization [sialolithiasis (salivary stone disease)]
Cardiovascular system (I00-I99)
- Myocarditis (inflammation of the heart muscle) with ECG changes (I41.1) [parotitis epidemica].
- Pericarditis (inflammation of the pericardium) [Coxsackie viral disease] [infection with staphylococci]
Infectious and parasitic diseases (A00-B99).
- Acute rheumatic fever [infection with group A β-hemolytic streptococci]
- Dissemination of pathogenic agents via blood and lymphatic circulation.
Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).
- Pancreatitis (inflammation of the pancreas) [parotitis epidemica (K87.1)]
Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).
- Abscess formation (formation of a pus cavity) [chronic recurrent parotitis; sialolithiasis].
- Chronification of sialadenitis
- Irreversible damage to the glandular parenchyma of the parotid gland due to increased pressure within the parotid capsule [parotitis].
- Irreversible damage to the ductal system
- Caries susceptibility [sialadenitis with xerostomia (dry mouth)]
- Lockjaw with infection of the parotid lodge [parotitis].
- Küttner tumor [chronic recurrent sialadenitis of the gl. submandibularis]
- Osteomyelitis risk during dental surgical procedures [radiation sialadenitis].
- Salivary gland atrophy
- Salivary gland fistula, intraoral
- Stenoses (narrowing) and strictures (high-grade narrowing).
Musculoskeletal system and connective tissue (M00-M99).
Neoplasms – tumor diseases (C00-D48).
- Non-Hogkin’s lymphoma (lymph node cancer) [chronic myoepithelial sialadenitis (MESA)/Sjögren’s syndrome/Sicca syndrome]
Ears – mastoid process (H60-H95).
- Transient (temporary) high-frequency deafness [approximately 4% in parotitis epidemica].
- Persistent unilateral deafness (permanent unilateral deafness) [1 in 20,000 cases in parotitis epidemica]
Psyche – Nervous System (F00-F99; G00-G99).
- Encephalitis (inflammation of the brain) [in parotitis epidemica less than 1% (G05.1)]
- Aseptic meningitis (meningitis) [parotitis epidemica 1 to 10% (G02.0)]
- Myelitis (inflammation of the spinal cord) [parotitis epidemica]
- Polyneuropathy [parotitis epidemica (G63.0)]
- Seizure disorder following CNS involvement.
- Irritation of the facial nerve [rarely, with deep inflammatory infiltration of purulent parotitis].
- Facial nerve damage [due to parotidectomy]
- [extirpation of the submandibular gland] damage of
- Lingual nerve
- Ramus marginalis mandibulae of the facial nerve
- Hypoglossal nerve
Pregnancy, childbirth and puerperium (O00-O99).
- Abortion (miscarriage) [parotitis epidemica] [perinatal cytomegalovirus disease].
Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).
- [Parotitis epidemica/mumps.]
- [Epididymitis (inflammation of the epididymis)]
- Mastitis (inflammation of the mammary glands)
- Nephritis (inflammation of the kidneys)
- Orchitis (testicular inflammation)
- Testicular atrophy 40 to 70% of cases.
- Abnormal spermiogram (sperm examination) up to 25% of cases.
- very rarely sterility (infertility)
- Oophoritis (ovarian inflammation) up to 5% of cases.
