Products Pegvaliase was approved in the United States in 2018 as an injectable (Palynziq). The drug is not yet registered in many countries. Structure and properties Pegvaliase is a phenylalanine-metabolizing enzyme consisting of recombinant phenylalanine ammonia lyase conjugated to -hydroxysuccinimide methoxy polyethylene glycol. The gene of the enzyme is derived from cyanobacterium . According to … Pegvaliase
Products Orlistat is available in many countries in the form of capsules and has been approved since 1998 (Xenical, 120 mg, Roche Pharmaceuticals). In 2009, it was also approved for self-medication after specialist consultation with healthcare professionals without a doctor’s prescription at half the dosage (Alli, 60 mg, GlaxoSmithKline). The generic Xenical drug Orlistat Sandoz … Orlistat: Drug Effects, Side Effects, Dosage and Uses
Products Pegaspargase is commercially available as an injectable (Oncaspar). The drug was approved in the United States in 2006, in the EU in 2016, and in many countries in 2017. Structure and properties Pegaspargase (PEG-L-asparaginase) is the pegylated enzyme L-asparaginase. The PEG units are covalently attached to the enzyme. Effects Pegaspargase (ATC L01XX24) has antileukemic … Pegaspargases
Methionine, along with cysteine, is the only sulfur-containing proteinogenic amino acid. In protein synthesis, L-methionine – its natural and biochemically active form – occupies a special position because it is always the first amino acid, the starter substance from which a protein is assembled. L-methionine is essential and serves primarily as a supplier of methyl … Methionine: Function & Diseases
The active ingredient methyldopa is an amino acid. It is produced synthetically and is used as an antihypertensive. In this context, it is primarily used for the treatment of arterial hypertension. What is methyldopa? The substance methyldopa appears at room temperature as a crystalline solid with virtually no color. The melting point of methyldopa is … Methyldopa: Effects, Uses & Risks
Products Glinides are commercially available in tablet form. Repaglinide (NovoNorm, USA: 1997) was the first to be approved in many countries in 1999, and nateglinide (Starlix) was approved a year later in 2000. Structure and properties The glinides differ structurally from the sulfonylureas. They are also referred to as meglitinide analogs. Repaglinide is a carbamoylmethylbenzoic … Glinides (Meglitinides): Diabetes Drugs
Choline is a widely used and indispensable biological agent. Many metabolic processes take place only with the cooperation of choline. Therefore, choline deficiency leads to a variety of health problems. What is choline? Choline is a quaternary ammonium compound, which is also a monohydric alcohol. Here, the nitrogen atom is surrounded by three methyl groups … Choline: Function & Diseases
The flesh of the watermelon is a delicious refreshment on hot summer days. Weighing up to 20 kilograms, the melon contains many valuable nutrients with few calories and is easy to obtain during the summer months. This is what you should know about the watermelon Watermelon is a low calorie and alkaline food. It contains … Watermelon: Intolerance & Allergy
Structure and properties Nucleic acids are biomolecules found in all living things on Earth. A distinction is made between ribonucleic acid (RNA, RNA, ribonucleic acid) and deoxyribonucleic acid (DNA, DNA, deoxyribonucleic acid). Nucleic acids are polymers composed of so-called nucleotides. Each nucleotide consists of the following three units: Sugar (carbohydrate, monosaccharide, pentose): ribose in RNA, … Nucleic Acids
Products Glyphosate was developed by Monsanto in the 1970s (Roundup) and is the world’s best-selling herbicide, with production volumes in the hundreds of thousands of tons. There are also numerous products on the market in many countries. Structure and properties Glyphosate or -(phosphonomethyl)glycine (C3H8NO5P, Mr = 169.1 g/mol) is an -phosphonomethyl derivative of the amino … Glyphosate
Phenethylamine (PEA) is the parent substance of catecholamines such as epinephrine, norepinephrine, or dopamine. It is often held responsible for triggering feelings of happiness. It occurs both widely in the plant kingdom and as a hormone in the human body. What is phenethylamine? Phenethylamine is considered the parent substance for catecholamines, which are widely used … Phenethylamine: Function & Diseases
Products Triptorelin is commercially available as an injectable. It has been approved in many countries since 1995. Structure and properties Triptorelin is a more potent derivative of gonadotropin-releasing hormone (GnRH). At position 6, the amino acid glycine has been replaced by D-tryptophan. It is a decapeptide. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly. Triptorelin: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly Effects Triptorelin (ATC L02AE04) is … Triptorelin
