Fibrates: Effects, Uses & Risks

Fibrates are carboxylic acids and belong to the organic compounds. Various representatives such as clofibrate, gemfibrozil and etofibrate are known on the market. Fibrates bind to specific receptors in cell organelles, causing a reduction in blood lipid levels. They are therefore used to treat lipid disorders such as high cholesterol or triglyceride levels. Fibrates should … Fibrates: Effects, Uses & Risks

Quinapril

Products Quinapril is commercially available in the form of film-coated tablets as a monopreparation (Accupro) and as a fixed combination with hydrochlorothiazide (Accuretic, Quiril comp). It has been approved in many countries since 1989. Generic versions are registered. Structure and properties Quinapril (C25H30N2O5, Mr = 438.5 g/mol) is present in drugs as quinapril hydrochloride, a … Quinapril

Indian Psyllium

Products Indian psyllium seeds and Indian psyllium husks are available in pharmacies and drugstores as open goods. There are also corresponding finished medicines on the market, such as Agiolax mite, Laxiplant, and Metamucil. These are usually powders or granules. See also under psyllium. Stem plant The parent plant is from the plantain family (Plantaginaceae). The … Indian Psyllium

ACE Inhibitors List, Effects, Side Effects

Products Most ACE inhibitors are commercially available in the form of tablets and film-coated tablets. The first agent from this group to be approved was captopril, in many countries in 1980. ACE inhibitors are often combined with the thiazide diuretic hydrochlorothiazide (HCT) fix. Structure and properties ACE inhibitors are peptidomimetics derived from peptides found in … ACE Inhibitors List, Effects, Side Effects

Pasireotide

Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide

Diabetes Mellitus Type 2: Causes and Treatment

Symptoms The possible acute symptoms of type 2 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), hyperosmolar hyperglycemic syndrome. Untreated diabetes is far from harmless and can lead in the longer term to … Diabetes Mellitus Type 2: Causes and Treatment

Saxagliptin

Products Saxagliptin is commercially available in the form of film-coated tablets (Onglyza). It was approved in many countries after sitagliptin (Januvia) and vildagliptin (Galvus) as the 3rd active ingredient from the gliptins group in February 2010. Since 2012, two additional combination products with metformin have been registered (Duoglyze, Kombiglyze XR). Kombiglyze XR entered the market … Saxagliptin

Slimming Products

Effects Antiadiposita differ in their effects. They inhibit appetite or increase satiety, reduce the absorption of food components in the intestine or promote their utilization, increase energy metabolism and degrading metabolic processes. The ideal slimming agent would enable rapid, high and stable weight loss and at the same time be very well tolerated and applicable … Slimming Products

Beta Blocker Effects and Side Effects

Products Beta-blockers are available in many countries in the form of tablets, film-coated tablets, sustained-release tablets, as capsules, solution, eye drops, and as injection and infusion solutions. Propranolol (Inderal) was the first representative of this group to appear on the market in the mid-1960s. Today, the most important active ingredients include atenolol, bisoprolol, metoprolol and … Beta Blocker Effects and Side Effects

Inhalable Insulin

Products An inhalable insulin preparation containing a rapid-acting human insulin was approved in the United States in 2014 (Afrezza, powder inhalation). The drug has not yet been registered in many countries. Pfizer’s first inhalable insulin Exubera was withdrawn from the market in 2007 for commercial reasons; see Exubera. Structure and properties Human insulin (C257H383N65O77S6, Mr … Inhalable Insulin

Injections

Products Injection preparations are approved as medicinal products. Structure and properties Injection preparations are sterile solutions, emulsions, or suspensions prepared by dissolving, emulsifying, or suspending the active ingredient and excipients in water or a suitable nonaqueous liquid (e.g., fatty oils). Compared with infusions, these are usually small volumes in the range of less than a … Injections

Gemfibrozil

Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil