Products Rivaroxaban is commercially available in the form of film-coated tablets (Xarelto, Xarelto vascular). It was approved in 2008 as the first agent in the direct factor Xa inhibitor group. Low-dose Xarelto vascular, 2.5 mg, was registered in many countries in 2019. Structure and properties Rivaroxaban (C19H18ClN3O5S, Mr = 435.9 g/mol) is a pure -enantiomer … Rivaroxaban
Products Most statins are commercially available in the form of film-coated tablets, and some are also available as capsules. The first active ingredient to be marketed was lovastatin from Merck in the United States in 1987. In many countries, simvastatin (Zocor) and, shortly thereafter, pravastatin (Selipran) were the first agents to be approved in 1990. … Statins
Products Enoxaparin is commercially available as a solution for injection (Clexane). It has been approved in many countries since 1988. Biosimilars were released in the EU in 2016 and in many countries in 2020 (Inhixa). Structure and properties Enoxaparin is present in the drug as enoxaparin sodium, the sodium salt of a low-molecular-weight heparin (LMWH) … Enoxaparin
Products Nadroparin is commercially available as a solution for injection (Fraxiparine, Fraxiforte). It has been approved in many countries since 1988. Structure and properties Nadroparin is present in the drug as nadroparin calcium. It is the calcium salt of a low-molecular-weight heparin obtained by depolymerization of heparin from the intestinal mucosa of pigs using nitrous … Nadroparin
Products Edoxaban was approved in many countries and in the United States in 2015 in film-coated tablet form (Lixiana, some countries: Savaysa). In Japan, edoxaban was approved as early as 2011. Structure and properties Edoxaban (C24H30ClN7O4S, Mr = 548.1 g/mol) is present in the drug as edoxabantosilate monohydrate, a white to pale yellow powder that … Edoxaban
Products Prasugrel is commercially available in the form of film-coated tablets (Efient). It was approved in many countries, in the EU and in the US in 2009. Generic versions were registered in 2019. Structure and properties Prasugrel (C20H20FNO3S, Mr = 373.4 g/mol) belongs to the group of thienopyridines and exists as a hydrochloride as a … Prasugrel
Products Fish oil is available in the form of soft capsules from various suppliers, such as Alpinamed, Biorganic, Burgerstein or Phytomed. Fish oil can also be supplied to the body through regular consumption of fish. At least one to two fish meals per week are recommended. Structure and properties Fish oil is a purified, winterized … Fish Oil
Products Omega-3 fatty acids are usually administered in the form of softgels. Oils for oral use are also available. Some foods are rich in omega-3 fatty acids (see below). Structure and properties The most important omega-3 fatty acids include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are polyunsaturated and long-chain fatty acids (PUFA: PolyUnsaturated … Omega 3 Fatty Acids Health Benefits
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Low-molecular-weight heparins are commercially available as injectable solutions, in the form of prefilled syringes, ampoules, and lancing ampoules. The active ingredients now commonly used in many countries were first approved in the late 1980s. Biosimilars are available in some countries. The active ingredients are abbreviated in English with the acronym LMWH (low molecular weight … Low-Molecular-Weight Heparins
Products Fondaparinux is commercially available as a solution for injection (Arixtra). It has been approved in many countries since 2002. Structure and properties Fondaparinux (C31H43N3Na10O49S8, Mr = 1728 g/mol) is a synthetic pentasaccharide belonging to the class of glycosaminoglycans. It is present in the drug as fondaparinux sodium. Effects Fondaparinux (ATC B01AX05) has antithrombotic properties. … Fondaparinux
Products Defibrotide was approved in many countries in 2020 as a concentrate for the preparation of an infusion solution (Defitelio). Structure and properties Defibrotide is a mixture of single-stranded oligonucleotides derived from porcine intestinal mucosa. Effects Defibrotide (ATC B01AX01) has antithrombotic, fibrinolytic, antiadhesive, and anti-inflammatory properties. Indications For the treatment of severe hepatic veno-occlusive disease … Defibrotide
