Symptoms Oral thrush is an infection of the mouth and throat with Candida fungi. Different manifestations are distinguished. The actual oral thrush is usually called acute pseudomembranous candidiasis. The leading symptom is the white to yellowish, small-spotted, partially intermingled coating of the mucous membranes in the mouth and throat area. It consists of epithelial cells, … Oral Thrush
Products Isavuconazonium sulfate is commercially available as a powder for a concentrate for the preparation of an infusion solution and in capsule form (Cresemba). It was approved in the US and EU in 2015 and in many countries in 2017. Structure and properties Isavuconazonium sulfate (C35H35F2N8O5S+ – HSO4– Mr = 814.8 g/mol) is a prodrug … Isavuconazonium Sulfate
Products Isoconazole is commercially available as a cream (Travogen, Travocort + diflucortolone valerate). It has been approved in many countries since 1980. The ovules are out of commerce. Structure and properties Isoconazole (C18H14Cl4N2O, Mr = 416.1 g/mol) is present in drugs as a racemate and as isoconazole nitrate, a white powder that is very sparingly … Isoconazole
Products Naftifine is commercially available as a gel and cream for external use. The drug has not yet been registered in many countries. Structure and properties Naftifine (C21H21N, Mr = 287.4 g/mol) is a lipophilic naphthalene derivative and belongs to the group of allylamines, which includes terbinafine. In pharmaceuticals, it is present as naftifine hydrochloride. … Naftifine
Symptoms A nail fungus manifests as a white to yellow-brown discoloration of the nail, thickening, softening and deformation. The most common form of nail fungus is the so-called distal-lateral subungual onychomycosis, which often occurs on the big toe. In this case, the fungus grows into the nail bed at the outer end and laterally at … Nail Fungus Causes and Treatment
Products Antifungal products are commercially available as creams, ointments, powders, solutions, tablets, capsules, and injectables, among others. Structure and properties The antifungal agents are a structurally heterogeneous class of agents. However, several groups can be identified within the antifungals, such as the azole antifungals and the allylamines (see below). Effects Antifungals have antifungal, fungistatic, or … Antifungals
Products Tioconazole is no longer available in many countries. Trosyd is out of commerce. Structure and properties Tioconazole (C16H13Cl3N2OS, Mr = 387.7 g/mol) Effects Tioconazole (ATC D01AC07, ATC G01AF08) is antifungal. Indications Fungal infections
Products Azole antifungals are approved in many countries for both topical and systemic treatment. They are available in numerous dosage forms-including creams, an oral gel, powders, sprays, tablets, capsules, injectables, vaginal creams, and vaginal tablets. The first azole antifungal came on the market in the 1950s. Structure and properties The name azole refers to heterocycles … Azole Antifungals
Symptoms Intertrigo (Latin for “rubbed sore”) is a common inflammatory skin condition that occurs on opposite skin surfaces in skin folds. It is initially manifested by a mild to severe redness that is approximately mirror image on both sides of the skin fold. It is often accompanied by itching, rash, burning sensation and pain. Papules … Intertrigo
Products Luliconazole is commercially available as a cream (Luzu). It was registered in the United States in 2013. The drug is not currently approved in many countries. In Japan, luliconazole has been on the market since 2005. Structure and properties Luliconazole (C14H9Cl2N3S2, Mr = 354.3 g/mol) is a chlorinated imidazole and 1,3-dithiolane derivative. Effects Luliconazole … Luliconazole
Products Triazolam is commercially available in tablet form (Halcion). It has been approved in many countries since 1978. Structure and properties Triazolam (C17H12Cl2N4, Mr = 343.2 g/mol) exists as a white crystalline powder that is poorly soluble in water. It is a triazole derivative (triazol-am). Effects Triazolam (ATC N05CD05) has sedative, antianxiety, anticonvulsant, amnesic, and … Triazolam
Products Amlodipine is commercially available in tablet form (Norvasc, generic). It has been approved in many countries since 1990. Amlodipine is also combined fixed with the following agents: Aliskiren, atorvastatin, perindopril, telmisartan, valsartan, olmesartan, hydrochlorothiazide, and indapamide. Structure and properties Amlodipine (C20H25ClN2O5, Mr = 408.9 g/mol) has a chiral center and is a racemate. It … Amlodipine (Norvasc)
