Products Oxiconazole was commercially available in the form of vaginal tablets (Oceral). It was approved in many countries since 1983. It was discontinued in 2017. Structure and properties Oxiconazole (C18H13Cl4N3O, Mr = 429.1 g/mol) is present in drugs as oxiconazole nitrate. It is an imidazole derivative. Effects Oxiconazole (ATC D01AC11, ATC G01AF17) has antifungal properties … Oxiconazole
Products Enilconazole is commercially available as an emulsion concentrate for animals. It has been approved in many countries since 1985. Structure and properties Enilconazole (C14H14Cl2N2O, Mr = 297.2 g/mol) is an imidazole derivative. Effects Enilconazole (ATCvet QD01AC90) has antifungal properties. Indications For the treatment of fungal diseases of the skin in horses, cattle, and dogs.
Symptoms Athlete’s foot (tinea pedis) usually develops between the toes and manifests as sometimes severe itching, burning, reddening of the skin, white softened, peeling and torn skin, skin blisters and dry skin. The symptoms also occur on the soles of the feet and are accompanied by hyperkeratosis. In the course, a difficult-to-treat nail fungus may … Athlete’s Foot
Products Medicines containing colchicine are no longer on the market in many countries. Drugs are available abroad that can be imported. It may also be possible to prepare an extemporaneous formulation in a pharmacy (difficulties: toxicity, substance). Stem plant Colchicine is the main alkaloid of the autumn crocus (Colchicaceae), which contains it particularly abundantly in … Colchicine
Products Efinaconazole is commercially available in the United States in the form of a solution (Jublia). The active ingredient has not yet been registered in many countries. Structure and properties Efinaconazole (C18H22F2N4O, Mr = 348.4 g/mol) structurally belongs to the triazole antifungals. Effects Efinaconazole has antifungal properties. The effects are due to inhibition of lanosterol … Efinaconazole
Products Tramadol is commercially available in the form of tablets, capsules, melting tablets, drops, effervescent tablets, suppositories, and as a solution for injection. (Tramal, generic). Fixed combinations with acetaminophen are also available (Zaldiar, generic). Tramadol was developed by Grünenthal in Germany in 1962 and has been approved in many countries since 1977 and in the … Tramadol: Drug Effects, Side Effects, Dosage and Uses
Products Pravastatin is commercially available in tablet form (Selipran, generics). It has been approved in many countries since 1990. Structure and properties Pravastatin (C23H36O7, Mr = 424.5 g/mol) is present in drugs as pravastatin sodium, a white to yellowish-white powder or crystalline powder that is readily soluble in water. It is not a prodrug, unlike … Pravastatin
Products Clotrimazole is commercially available as creams, creams, ointments, sprays, vaginal tablets, and vaginal creams alone or in combination with other active ingredients (e.g., Canesten, Gyno-Canesten, Imacort, Imazol, Triderm). It has been approved in many countries since 1973. Structure and properties Clotrimazole (C22H17ClN2, Mr = 344.8 g/mol) is a chlorinated phenylmethylimidazole derivative. It exists as … Clotrimazole
Products Ketoconazole has been approved in many countries since 1981 and is now only commercially available as a shampoo and as a cream for external treatment (Nizoral, generics). Nizoral tablets were taken off the market in 2012 due to declining demand. This article refers to external use. Structure and properties Ketoconazole (C26H28Cl2N4O4, Mr = 531.4 … Ketoconazole
CYP450 Cytochromes P450s are a family of enzymes that are of paramount importance in drug biotransformation. The most important isoenzymes for drug metabolism are: CYP1A1, CYP1A2 CYP2B6 CYP2C9, CYP2C19 CYP2D6 CYP2E1 CYP3A4, CYP3A5 and CYP3A7 The number after the abbreviation CYP stands for the family, the following letter for the subfamily and the last number … Cytochrome P450 (CYP)
Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide
Products Itraconazole is commercially available in capsule form and as an oral solution (Sporanox, generic). It has been approved in many countries since 1992. Sporanox infusion concentrate is no longer available. Structure and properties Itraconazole (C35H38Cl2N8O4, Mr = 705.6 g/mol) exists as a white powder that is practically insoluble in water. It belongs to the … Itraconazole
