Products Enrofloxacin is commercially available as a solution, solution for injection, and tablets. It has been approved in many countries since 1989. Structure and properties Enrofloxacin (C19H22FN3O3, Mr = 359.4 g/mol) Effects Enrofloxacin (ATCvet QJ01MA90) has bactericidal properties. Indications Bacterial infectious diseases in numerous animals.
Effect Antibacterial Bakeriostatic Antiparasitic against protozoa Mechanism of action Sulfonamides inhibit the synthesis of folic acid in microorganisms. They are structural analogues (antimetabolites) of the natural substrate p-aminobenzoic acid and competitively displace it. Trimethoprim, used in combination with sulfamethoxazole, has a synergistic effect. Indications Bacterial infectious diseases caused by: Streptococcus Pneumococcus Actinomycetes Nocardia, e.g. nocaridosis … Sulfonamides
Products Netilmicin is no longer available in many countries. Netromycin is out of commerce. Effects Netilmicin (ATC J01GB07) is bactericidal. Indications Bacterial infectious diseases
Products Amikacin is commercially available as a solution for injection (Amikin). It has been approved in many countries since 1976. Structure and properties Amikacin (C22H43N5O13, Mr = 585.6 g/mol) is semisynthetically prepared from kanamycin A. It is found in drugs as amikacin sulfate, a white powder that is readily soluble in water. Effects Amikacin (ATC … Amikacin
Products The first active ingredient in the quinolone group to be introduced was nalidixic acid in 1967 (NegGram). It is no longer commercially available in many countries. Other drugs are available today (see below). Various dosage forms are available, for example, film-coated tablets, oral suspensions, eye drops, ear drops, and infusion solutions. Due to adverse … Quinolone
Products Gramicidin is contained in topically applied medicines, for example, creams, ointments, lozenges, eye drops, and ear drops. These are usually combination preparations. Gramicidin was discovered in the late 1930s by René J. Dubos in New York at the Rockefeller Institute for Medical Research. It is therefore also known as gramicidin D. Structure and properties … Gramicidin
Products Tobramycin is commercially available as a solution for injection, solution for inhalation, and in the form of eye drops, eye gel, and eye ointment. This article refers to the solution for injection (Obracin), which has been approved in many countries since 1974. See also tobramycin inhalation and tobramycin eye drops. Structure and properties Tobramycin … Tobramycin
Products Lomefloxacin is included in eye drops in many countries (Okacin). Maxaquin film-coated tablets, approved in 1992, are no longer available (off label). Structure and properties C17H19F2N3O3, Mr = 351.35 g/mol Effects Lomefloxacin (ATC J01MA07) is bactericidal. Indications Bacterial infectious diseases Cf. Quinolones
Products Roxithromycin was commercially available in tablet form (Rulid). It is no longer available in many countries. Effects Roxithromycin is (ATC J01FA06) bacteriostatic. It inhibits bacterial protein synthesis; see under macrolides. Indications Bacterial infectious diseases
Products Tigecycline is commercially available as a dry substance for the preparation of an infusion solution (Tygacil). It has been approved in many countries since 2007. Effects Tigecycline (ATC J01AA12) has bacteriostatic properties. It inhibits translation in bacterial protein synthesis by binding to the 30S subunit of ribosomes and preventing the attachment of aminoacyl-tRNA molecules … Tigecycline
Products Injectables containing cefotaxime are no longer available in many countries Claforan is off the market. It was approved in 1981. Structure and properties Cefotaxime (C16H17N5O7S2, Mr = 455.5 g/mol) Effects Cefotaxime (ATC J01DA10) has bactericidal properties by inhibiting cell wall synthesis. Indications Bacterial infectious diseases
Products Spiramycin is currently marketed in many countries exclusively as a veterinary drug. Rovamycine tablets, which were approved in 1956, are no longer registered. Structure and properties Spiramycin (C43H74N2O14, Mr = 843.1 g/mol) is obtained from certain strains of or prepared by other methods. The major component is spiramycin I. Spiramycin II and II are … Spiramycin
