Products Cefaclor is commercially available as sustained-release film-coated tablets and as a suspension (Ceclor). It has been approved in many countries since 1978. Structure and properties Cefaclor monohydrate (C15H14ClN3O4S – H2O, Mr = 385.8) is a white to pale yellow powder that is sparingly soluble in water. It is a semisynthetic antibiotic and has structural … Cefaclor
Products Cefamandol is commercially available as an injectable (Mandokef). It has been approved in many countries since 1978. Structure and properties Cefamandol (C18H18N6O5S2, Mr = 462.5 g/mol) is present in drugs as cefamandolafate, a white powder that is readily soluble in water. Effects Cefamandol (ATC J01DA07) has bactericidal properties. The effects are due to inhibition … Cefamandol
Products Cefixime was commercially available in tablet form (Cephoral). It had been approved in many countries since 1992. Structure and properties Cefixime (C16H15N5O7S2, Mr = 453.4 g/mol) is a white powder that is sparingly soluble in water. It is a semisynthetic cephalosporin. In medicinal products, it is anhydrous. Effects Cefixime (ATC J01DD08) is bactericidal against … Cefixime
Products Injectables containing cefotaxime are no longer available in many countries Claforan is off the market. It was approved in 1981. Structure and properties Cefotaxime (C16H17N5O7S2, Mr = 455.5 g/mol) Effects Cefotaxime (ATC J01DA10) has bactericidal properties by inhibiting cell wall synthesis. Indications Bacterial infectious diseases
Products Cefpodoxime is commercially available as film-coated tablets and as granules for preparation of a suspension (Podomexef, generics). It has been approved in many countries since 1991. Structure and properties Cefpodoxime (C15H17N5O6S2, Mr = 427.5 g/mol) is present in drugs as cefpodoxime proxetil. It is an ester prodrug and is rapidly converted to cefpodoxime in … Cefpodoxime
Products Cefprozil was commercially available as film-coated tablets and as a suspension (Procef). It was approved in many countries in 1995 and is currently no longer available. Structure and properties Cefprozil (C18H19N3O5S, Mr = 389.4 g/mol) is present in drugs as cefprozil monohydrate, a white to yellowish powder that is sparingly soluble in water. Effects … Cefprozil
Products Ceftarolinefosamil is commercially available as a powder for the preparation of a concentrate for an infusion solution (Zinforo). It has been approved in many countries since 2013. Structure and properties Ceftarolinefosamil (C22H21N8O8PS4, Mr = 684.7 g/mol) is present in drugs as ceftarolinefosamil monoacetate monohydrate, a yellowish-white powder. Ceftarolinefosamil is a prodrug that is enzymatically … Ceftarolinefosamil
Products Cefazolin is commercially available as an injection and infusion preparation (Kefzol, generics). It has been approved in many countries since 1974. Structure and properties Cefazolin (C14H14N8O4S3, Mr = 454.5 g/mol) is present in drugs as cefazolin sodium, a white powder that is readily soluble in water. Effects Cefazolin (ATC J01DA04) is bactericidal. Its effects … Cefazolin
Products Cefepime is commercially available as a powder for solution for injection or infusion (generic). It has been approved in many countries since 2007. Structure and properties Cefepime (C19H24N6O5S2, Mr = 480.6 g/mol) is present in drugs as cefepim dihydrochloride monohydrate, a white to yellowish powder that is readily soluble in water. Effects Cefepime (ATC … Cefepime
Products Ceftazidime is commercially available as a solution for injection and infusion (Fortam, generic). It has been approved in many countries since 1984. In 2019, a fixed-dose combination with the beta-lactamase inhibitor avibactam was registered; see Avibactam (Zavicefta). Structure and properties Ceftazidime (C22H22N6O7S2 – 5 H2O, Mr = 637 g/mol) is a white crystalline powder … Ceftazidime
Products Ceftibuten was commercially available in many countries as a powder for preparation of a suspension and in capsule form (Cedax). It had been approved in many countries since 1994. Structure and properties Ceftibuten (C15H14N4O6S2, Mr = 410.4 g/mol) is present in drugs anhydrous or as ceftibutene dihydrate. Effects Ceftibuten (ATC J01DA39) has bactericidal properties … Ceftibuten
Products Ceftobiprole was approved in many countries in 2009 as a powder for a concentrate for the preparation of an infusion solution (Zevtera). Structure and properties Ceftobiprole (C20H22N8O6S2, Mr = 534.6 g/mol) is present in the drug in the form of the prodrug ceftobiprole medocaril and as a sodium salt. The prodrug is converted to … Ceftobiprole
