Enterohepatic Circulation

Definition Pharmaceutical agents are excreted primarily in the urine and, via the liver, in the bile in the stool. When excreted via the bile, they re-enter the small intestine, where they may be reabsorbed. They are transported back to the liver via the portal vein. This repetitive process is called the enterohepatic circulation. It prolongs … Enterohepatic Circulation

Estriol

Products Estriol is commercially available in many countries as vaginal gel, vaginal cream, vaginal suppositories, vaginal tablets, and tablets for peroral therapy. This article refers to topical use. Structure and properties Estriol (C18H24O3, Mr = 288.4 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a natural metabolite of … Estriol

Progestin: Function & Diseases

A progestin is a so-called corpus luteum hormone. Along with estrogens, progestins belong to the female sex hormones, they are so-called steroid hormones. What is progestin? Progestins are so-called steroids, the basic structure of which is pregnane. Progesterone, pregnanediol and pregnenolone are the most important representatives of progestins. The natural progestin is a corpus luteum … Progestin: Function & Diseases

Rhinitis Medicamentosa

Symptoms Rhinitis medicamentosa manifests as a stuffy nose with swollen and histologically altered nasal mucosa. Causes It is the result of prolonged use of decongestant nasal medications (sprays, drops, oils, gels) containing active ingredients such as xylometazoline, oxymetazoline, naphazoline, or phenylephrine. Because the nasal mucosa no longer swells on its own and habituation occurs, the … Rhinitis Medicamentosa

Exemestane

Products Exemestane is commercially available in the form of dragées and film-coated tablets (Aromasin, generics). It has been approved in many countries since 1999. Structure and properties Exemestane (C20H24O2, Mr = 296.4 g/mol), unlike other aromatase inhibitors, has a steroidal structure and resembles the natural substrate androstenedione. It exists as a white to slightly yellowish … Exemestane

Promestria

Products Promestrien was commercially available in the form of vaginal capsules and as a vaginal cream (Colpotrophine). It was approved in many countries in 1982 and is now no longer available. Structure and properties Promestriene (C22H32O2, Mr = 328.5 g/mol) is an alkyl derivative of the natural estrogen estradiol. Effects Promestriene (ATC G03CA09) has estrogenic … Promestria

Menopause: Climacteric

Menopause usually occurs in women between the ages of 45 and 60. During this time, the body’s production of sex hormones decreases and the ability to reproduce recedes. At the same time, but also four to five years earlier, more or less pronounced complaints such as hot flashes, sweating and emotional changes can cause problems. … Menopause: Climacteric

Vaginal Tablets

Products Some vaginal tablets are commercially available. Also used are vaginal suppositories and vaginal capsules. Structure and properties Vaginal tablets are solid, single-dose preparations intended for vaginal use. In general, they meet the definition of non-coated tablets or film-coated tablets. Detailed information can be found under the relevant articles. Vaginal tablets contain the same excipients, … Vaginal Tablets

Vaginal Suppositories

Products Vaginal suppositories are commercially available as drugs and medical devices. Listed below are some active ingredients which are administered vaginally: Estrogens: estriol Progestins: progesterone Antifungals: Econazole, ciclopirox Antiparasitics: Metronidazole, Clindamycin Antiseptics: Povidone–iodine, formerly boric acid. Probiotics: Lactobacilli The egg-shaped vaginal suppositories are also called ovules (singular ovulum). Structure and properties Vaginal suppositories are dosage … Vaginal Suppositories

Gemfibrozil

Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil

Omega-3 Fatty Acids and Pregnancy

Products In many countries, omega-3 fatty acids are marketed as drugs, foods, and dietary supplements. Some products are marketed specifically for pregnancy and lactation, such as Elevit Omega 3. Many multivitamin preparations for pregnancy do not contain omega-3 fatty acids. Structure and properties Among the most active omega-3 fatty acids are docosahexaenoic acid (DHA) and … Omega-3 Fatty Acids and Pregnancy