Products Rituximab is commercially available as a concentrate for the preparation of an infusion solution and as a solution for subcutaneous injection (MabThera, MabThera subcutaneous). It has been approved in many countries and in the United States since 1997 and in the EU since 1998. Biosimilars are available in some countries, including many (2018, Rixathon, … Rituximab
Background The skin of jellyfish contains so-called cnidocytes, which are used against prey and enemies when they come into contact with the skin. When appropriately irritated, a cnidocyst is ejected at high speed like a kind of harpoon, injecting a venom deep into the victim’s skin. This venom causes mild to fatal toxic and allergic … Jellyfish Repellent
Products Quinagolide is commercially available in tablet form (Norprolac). It has been approved in many countries since 1994. Structure and properties Quinagolide (C20H33N3O3S, Mr = 395.56 g/mol) is a non-ergoline dopamine agonist with a similar structure to apomorphine. It is present in drugs as quinagolide hydrochloride. Effects Quinagolide (ATC G02CB04) has dopaminergic properties and inhibits … Quinagolide
Products Quinisocaine was commercially available in many countries as an ointment (isoquinol) since 1973. In 2013, distribution was discontinued. Structure and properties Quinisocaine (C17H24N2O, Mr = 272.4 g/mol) is an isoquinoline derivative and is present in the drug as quinisocaine hydrochloride. It is classified as an amide-type local anesthetic. Effects Quinisocaine (ATC D04AB05) has local … Quinisocaine
Products Minoxidil is commercially available as a solution and in some countries also as a foam (Regaine, generics, USA: Rogaine). It has been approved in many countries since 1987. The brand name plays on the English verb , which translates as to recover or get back. This article refers to external use. Tablets also exist … Minoxidil
Effects Miotic: constricts the pupils Indication Miosis, e.g., during eye surgery. Agents Parasympathomimetics: Acetylcholine Alpha blocker: Dapiprazole
Products Mirabegron is commercially available in the form of sustained-release film-coated tablets (Betmiga, USA: Myrbetriq). It was approved in the US and EU in 2012 and in many countries in 2014. Mirabegron was the first agent from the beta3 agonist group to be approved for the treatment of irritable bladder. It was originally intended to … Mirabegron
Products Mirtazapine is commercially available in the form of film-coated tablets and meltable tablets (Remeron, generics). It has been approved in many countries since 1999. Structure and properties Mirtazapine (C17H19N3, Mr = 265.35 g/mol) is a racemate and exists as a white crystalline powder that is sparingly soluble in water. It is structurally closely related … Mirtazapine: Drug Effects, Side Effects, Dosage and Uses
Cough syrup as an intoxicant Many antirritant cough syrups contain active ingredients that are psychoactive in high doses and can be abused as intoxicants. Substances include, for example: Opioids such as codeine, dihydrocodeine and ethylmorphine. NMDA antagonists: dextromethorphan Antihistamines such as diphenhydramine and oxomemazine. Phenothiazines: promethazine (out of commerce). Such drugs are unlike other drugs … Misuse of Cough Syrup
Products Mitomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Mitem). Structure and properties Mitomycin (C15H18N4O5, Mr = 334.3 g/mol) exists as a blue-violet crystalline powder or as crystals and is sparingly soluble in water. It is formed by a strain of. Mitomycin was first isolated in … Mitomycin
Products Indigocarmine is available as a pure substance in specialized stores. Structure and properties Indigocarmine (C16H8N2Na2O8S2, Mr = 466.4 g/mol) exists as a blue powder that is soluble in water. The solutions are either yellow or blue depending on the pH. Areas of application Dye for many drugs (e.g. Rohypnol, Viagra, Truvada). Dye for food … Indigocarmine
Products Indometacin is commercially available as sustained-release capsules, indometacin eye drops (Indophtal), and solution for application (Elmetacin). This article refers to oral administration. The sustained-release capsules have been on the market in many countries since 1995 (Indocid, generic). Structure and properties Indomethacin (C19H16ClNO4, Mr = 357.8 g/mol) is an indoleacetic acid derivative. It exists as … Indometacin
