Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products Ergocalciferol (vitamin D2, calciferol) is commercially available in many countries, including as a dietary supplement in the form of capsules. Vitamin D2 is much less commonly used than cholecalciferol (vitamin D3) in many countries. In the United States, on the other hand, ergocalciferol is more traditionally used. Structure and properties Ergocalciferol (C28H44O, Mr = … Ergocalciferol (Vitamin D2)
Products Azelaic acid is commercially available as gel and cream (Skinoren). It has been approved in many countries since 1990. Structure and properties Azelaic acid (C9H16O4, Mr = 188.2 g/mol) is a saturated dicarboxylic acid. It exists as a white, odorless, crystalline solid that is poorly soluble in water at 20°C but dissolves well in … Azelaic Acid for Skin Problems
Products Eribulin is commercially available as a solution for injection (Halaven). It was approved in many countries and in the EU in 2011. In the United States, it has been registered since 2010. Structure and properties Eribulin is present in drugs as eribulin mesilate (C40H59NO11 – CH4O3S, Mr = 826.0 g/mol), a white crystalline powder … Eribulin
Products The marketing of medicinal products containing dihydroergotamine has been discontinued in many countries (e.g., Dihydergot tablets and nasal spray, Ergotonin, Effortil plus, Old Tonopan, and others). The approval of Dihydergot tablets was cancelled on February 1, 2014, because the benefits no longer outweighed the potential risks, according to drug regulators. Structure and properties Dihydroergotamine … Dihydroergotamine
Products Risankizumab was approved in the United States and in many countries in 2019 as a solution for injection (Skyrizi). Structure and properties Risankizumab is a humanized IgG1 monoclonal antibody produced by biotechnological methods. Effects Risankizumab (ATC L04AC) has selective immunosuppressive and anti-inflammatory properties. The antibody binds to the p19 subunit of human interleukin-23 (IL-23), … Risankizumab
Products Dihydropyridines are commercially available in many countries in the form of film-coated tablets, sustained-release tablets, capsules, and injectables. Nifedipine from Bayer (Adalat) was the first active ingredient from this group to enter the market in the mid-1970s. Today, amlodipine (Norvasc, generics) is most commonly prescribed. Structure and properties The name 1,4-dihydropyridines is derived from … Dihydropyridine
Products Risperidone is commercially available as film-coated tablets, meltable tablets, an oral solution, and a suspension for intramuscular administration (Risperdal, generics). The active ingredient has been approved in many countries since 1994. Structure and properties Risperidone (C23H27FN4O2, Mr = 410.5 g/mol) exists as a white powder that is practically insoluble in water. It is a … Risperidone: Drug Effects, Side Effects, Dosage and Uses
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Rivipansel is currently in clinical development at GlycoMimetics and Pfizer. The drug is not yet commercially available. Structure and properties Rivipansel (C58H74N6O31S3, Mr = 1447.4 g/mol) is a glycomimetic developed by the research group led by Prof. Beat Ernst at the Institute of Molecular Pharmacy, University of Basel, in collaboration with GlycoMimetics. Effects Rivipansel … Rivipansel (GMI-1070)
Products Rizatriptan is commercially available in tablet and lingual (melting) tablet form (Maxalt, generics). It has been approved in many countries since 2000. Generic versions went on sale in 2015. Structure and properties Ritatriptan (C15H19N5, Mr = 269.3 g/mol) is present in drugs as rizatriptan benzoate, a white crystalline powder that is soluble in water. … Rizatriptan
Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
