Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil
Products Avelumab was approved in the United States, the EU, and many countries in 2017 as a concentrate for the preparation of an infusion solution (Bavencio). Structure and properties Avelumab is a human IgG1λ monoclonal antibody against programmed cell death ligand 1 (PD-L1) with a molecular weight of 147 kDa. It is produced by biotechnological … Avelumab
Products Demeclocycline is commercially available as a paste and cement powder (Ledermix). It has been approved in many countries since 1963. Structure and properties Demeclocycline (C21H21ClN2O8, Mr = 464.85 g/mol) Effects Demeclocycline (ATC A01AC01) has antibacterial properties. Indications For pulpitis prophylaxis For conservative treatment of acute pulpitis with vital preservation of the pulp (pulpitis acuta). … Demeclocycline
Products Vaginal suppositories containing dehydroepiandrosterone were registered in many countries in 2020 (Intrarosa). The active ingredient is referred to as prasterone in medications. Furthermore, an intramuscular injection solution containing the prodrug prasterone antate has been registered in many countries (Gynodian Depot). In the United States, dietary supplements (“dietary supplements”) containing dehydroepiandrosterone (DHEA) have been allowed … Dehydroepiandrosterone (DHEA)
Products Buformin (Silubin retard, dragées) is no longer commercially available in many countries and many more because of the potential adverse effects. Structure and properties Buformin (C6H15N5, Mr = 157.2 g/mol) is a 1-butylbiguanide with a similar structure to metformin from the same drug group. It is present in drugs as buformin hydrochloride. Effects Buformin … Buformin
Products Cladribine was approved for the treatment of multiple sclerosis in the EU in 2017 and in the United States and many countries in 2019 in tablet form (Mavenclad). Cladribine has also been commercially available as an infusion and injection solution in many countries since 1998 (Litak). This article relates to MS therapy. Structure and … Cladribine
Products Bumetanide was commercially available in tablet form (Burinex, off label). It was approved in many countries in 1974. Structure and properties Bumetanide (C17H20N2O5S, Mr = 364.4 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Bumetanide (ATC C03CA02) is diuretic with rapid onset and short duration of action. Indications Oedema … Bumetanide
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron
Products Clavulanic acid is sold exclusively in combinations with antibiotic amoxicillin. In addition to the original Augmentin, numerous generics are also available. Structure and properties Clavulanic acid (C8H9NO5, Mr = 199.16 g/mol) is present in drugs as potassium clavulanate, the potassium salt of clavulanic acid. Potassium clavulanate is a white, crystalline, hygroscopic powder that is … Clavulanic Acid
Products No drugs containing clebopride are on the market in many countries. Structure and properties Cleboprid (C20H24ClN3O2, Mr = 373.9 g/mol) is present in drugs as clebopride malate, a white crystalline powder that is sparingly soluble in water. Clebopride is a substituted benzamide. Effects Clebopride (ATC A03FA06) has prokinetic and antiemetic properties. Indications For the … Cleboprid
