Products Dibenzepine was still commercially available as extended-release film-coated tablets (Noveril TR, Novartis, formerly Wander). It was approved in many countries in 1968 and withdrawn from the market in 2016. Structure and properties Dibenzepine (C18H21N3O, Mr = 295.4 g/mol) is present in drugs as dibenzepine hydrochloride. It belongs to the dibenzepine group. Effects Dibenzepine (ATC … Dibenzepine
Products Desfesoterodine was approved in many countries in 2019 in sustained-release tablet form (generic, tovedeso). Structure and properties Desfesoterodine (C22H31NO2, Mr = 341.5 g/mol) is the active metabolite of the prodrug fesoterodine as well as tolterodine (detrusitol). It is also referred to as 5-hydroxymethyltolterodine. In the drug, it is present as desfesoterodine succinate. Effects Desfesoterodine … Desfesoterodine
Products Levodopa is marketed exclusively as combination products together with a peripheral decarboxylase inhibitor (carbidopa or benserazide) or a COMT inhibitor (entacapone). It has been approved in many countries since 1973 and is commercially available in tablet, capsule, suspendable tablet, and sustained-release tablet forms, among others. Structure and properties Levodopa (C9H11NO4, Mr = 197.2 g/mol) … Levodopa: Drug Effects, Side Effects, Dosage and Uses
Products Oxomemazine is commercially available as syrups (Toplexil N syrup). It has been approved in many countries since 1966. In France, several drugs containing oxomemazine are on the market. Structure and properties Oxomemazine (C18H22N2S, Mr = 298.4 g/mol) is a phenothiazine closely related structurally to the neuroleptic promethazine. It exists as a white, crystalline powder … Oxomemazine
Products Oxymetazoline is commercially available in the form of nasal drops and as a nasal spray with or without a preservative (Nasivin, Vicks Sinex). It has been approved in many countries since 1972. Oxymetazoline is also used to treat rosacea; see oxymetazoline cream. Structure and properties Oxymetazoline (C16H24N2O, Mr = 260.4 g/mol) is present in … Oxymetazoline
Products Tuaminoheptane is commercially available in combination with acetylcysteine in the form of a nasal spray (rinofluimucil). It has been approved in many countries since 1990. Structure and properties Tuaminoheptane (C7H17N, Mr = 115.2 g/mol) is a primary amine. Effects Tuaminoheptane (ATC R01AA11, ATC R01AB08) has sympathomimetic, vasoconstrictor, and decongestant properties. It facilitates breathing and … Tuaminoheptane
Products Phenylpropanolamine is no longer on the market as a human drug in many countries. It was formerly contained in Astho-Med Syrup, Contac, Dimetane, Dimetapp, and Slim Caps, among others. Structure and properties Phenylpropanolamine (C9H13NO, Mr = 151.21 g/mol) has a phenylethylamine structure and exists as a racemate. The salt phenylpropanolamine hydrochloride is a white … Phenylpropanolamine
Products Naphazoline is commercially available in the form of eye drops (Oculosan, Collyre bleu) in combination with other active ingredients. Decongestant nasal sprays containing naphazoline are currently no longer available in many countries. Nasal spray comp Spirig is out of trade. Structure and properties Naphazoline is often present in drugs as naphazoline nitrate (C14H15N3O3, Mr … Naphazoline
