Products Xylometazoline is commercially available in the form of nasal sprays and as nasal drops (Otrivin, generics, combination products, for example with dexpanthenol). It was developed at Ciba and has been approved in many countries since 1958. Structure and properties Xylometazoline is present in drugs as xylometazoline hydrochloride (C16H24N2 – HCl, Mr = 280.8 g/mol), … Xylometazoline
Products Scopolamine is currently sold in many countries exclusively in the form of eye drops. The transdermal patch Scopoderm TTS and other medications are no longer available. In some countries, other medicines containing scopolamine are available, such as Kwells motion sickness tablets and the Transderm Scop transdermal patch. This article refers to peroral use. In … Scopolamine
Products Scopolamine butylbromide is available worldwide in the form of dragées, suppositories, and as a solution for injection. It has been commercially available in Germany and in many countries since 1952 (Buscopan, Boehringer Ingelheim) in the form of the dragées and suppositories even without a doctor’s prescription. In some countries, a combination with the analgesic … Scopolamine Butyl Bromide
Products Meclozine is marketed as a fixed combination with caffeine and the vitamin pyridoxine in the form of capsules and suppositories (Itinerol B6). It has been approved in many countries since 1953. In some countries, the active ingredient is also called. Itinerol dragées went out of commerce in 2015. Structure and properties Meclozine (C25H27ClN2, Mr … Meclozin
Products Chlorphenamine is commercially available as a monopreparation (Arbid N drops) and as a combination preparation (e.g., Fluimucil Flu Day & Night, Solmucalm, Triocaps). The enantiomer dexchlorpheniramine was formerly available in tablet form. Rhinopront is out of commerce. Structure and properties Chlorphenamine (C16H19ClN2, Mr = 274.79 g/mol) is a chlorinated pheniramine and is also known … Chlorphenamine
Products Spasmo-Canulase Bitabs (originally Wander, then Sandoz, Novartis, GSK) went on sale in many countries in 1964. In 2017, distribution was discontinued for production reasons. Procurement of the seven active ingredients apparently became increasingly difficult. Ingredients In the fast-dissolving shell of the tablets: Metixene (anticholinergic). Pepsin (digestive enzyme) Dimethicone (defoamer) Glutamic acid hydrochloride (acid) In … Spasmo-Canulase
Products Doxylamine is commercially available in many countries as a solution (Sanalepsi N). It is also contained in Vicks MediNait juice in combination with dextromethorphan, ephedrine, and acetaminophen. In 2020, hard capsules containing doxylamine and pyridoxine were approved in many countries for the treatment of nausea and vomiting in pregnancy (Cariban). Pharmacies also make a … Doxylamine
Products Imipramine was commercially available in the form of dragées (Tofranil). It was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). It was approved in many countries in 1958 as the first active ingredient in the tricyclic antidepressant group. In … Imipramine: Drug Effects, Side Effects, Dosage and Uses
Products Fesoterodine is commercially available in the form of sustained-release tablets (Toviaz). It has been approved in the EU since 2007 and in many countries since 2008. Structure and properties Fesoterodine (C26H37NO3, Mr = 411.58 g/mol) is present in drugs as fesoterodine fumarate. It is an ester prodrug and is rapidly and completely hydrolyzed to … Fesoterodine
Products Trospium chloride is commercially available in the form of dragées (Spasmo-Urgenin Neo, Spasmex). It has been approved in many countries since 1983. Structure and properties Trospium chloride (C25H30ClNO3, Mr = 428.0 g/mol) is a quaternary amine that exists as a chloride salt. It is a fine, colorless to slightly yellow, crystalline substance. Trospium chloride … Trospium Chloride
Products Hydroxyzine is commercially available in the form of film-coated tablets and as a syrup (Atarax). It has been approved in many countries since 1956. Structure and properties Hydroxyzine (C21H27ClN2O2, Mr = 374.9 g/mol) is a piperazine derivative. It is present in drugs as hydroxyzine hydrochloride, a white crystalline powder that is readily soluble in … Hydroxyzine
Products Atomoxetine is commercially available in capsule form and as a drinkable solution (Strattera, generics). It was approved in many countries in 2009. Structure and properties Atomoxetine (C17H21NO, Mr = 255.4 g/mol) is present in drugs as atomoxetine hydrochloride. It is structurally closely related to the SSRI fluoxetine (Fluctine, Prozac, generics), which was also developed … Atomoxetine
