Products Lofexidine was approved in the United States in 2018 in film-coated tablet form (Lucemyra). In the United Kingdom, the agent was approved for the treatment of opioid withdrawal back in the early 1990s (UK: BritLofex). Structure and properties Lofexidine (C11H12Cl2N2O, Mr = 259.1 g/mol) is present in the drug as lofexidine hydrochloride, a white … Lofexidine
Products Bupropion is commercially available in the form of sustained-release tablets (Wellbutrin XR, Zyban). The two drugs are used for different indications (see below). The active ingredient has been approved in many countries since 1999. Structure and properties Bupropion (C13H18ClNO, Mr = 239.7 g/mol) is present as a racemate and as bupropion hydrochloride, a white … Bupropion
Products Pregabalin is commercially available in capsule form and as an oral solution (Lyrica, generics). It was approved in the United States and EU in 2004 and in many countries in 2005. Structure and properties Pregabalin (C8H17NO2, Mr = 159.2 g/mol) exists as a white crystalline powder that is soluble in water. It was developed … Pregabalin
Products In many countries, finished medicines containing cocaine are currently no longer commercially available. However, they can be prepared as an extemporaneous prescription in a pharmacy. Cocaine is subject to the Narcotics Act and requires an aggravated prescription, but it is not banned as a drug. It is also sold as an illegal narcotic on … Cocaine: Drug Effects, Side Effects, Dosage and Uses
Products Canrenone is commercially available as an injectable (Soldactone). It has been approved in many countries since 1975. Structure and properties Canrenone (C22H28O3, Mr = 340.5 g/mol) is an active metabolite of spironolactone (aldactone) and, unlike the latter, is soluble in water. Canrenone is present in drugs as potassium canrenoate, the potassium salt of canrenoic … Canrenon
Products MDEA is one of the narcotics and banned substances in many countries. It is not commercially available. MDEA was first mentioned in the 1970s in the books of Alexander Shulgin. Structure and properties Methylenedioxyethylamphetamine (C12H17NO2, Mr = 207.3 g/mol) is a 3,4-methylenedioxy derivative of an -ethylated amphetamine. It is structurally closely related to ecstasy … MDEA (Methylenedioxyethylamphetamine)
Products 3,4-Methylenedioxypyrovalerone (MDPV) is not licensed in many countries. It is one of the prohibited narcotics (d) and is therefore not commercially available. MDPV was developed as a designer drug and was therefore initially available legally in many countries. It was marketed as “bath salts” to give it a legal appearance. Structure and properties MDPV … MDPV
Products Sunovion’s dasotraline is in the regulatory phase and is therefore not yet available. Structure and properties Dasotralin (C16H15Cl2N, Mr = 292.2 g/mol) is a diastereomer of the desmethyl metabolite of sertraline (Zoloft, generics). Effects Dasotraline selectively inhibits the reuptake of the neurotransmitters dopamine and norepinephrine into presynaptic neurons in the central nervous system. The … Dasotralin
Products Nortriptyline was commercially available in the form of film-coated tablets (nortrilen). It was approved in many countries in 1964. It was discontinued from distribution in 2016. Structure and properties Nortriptyline (C19H21N, Mr = 263.4 g/mol) is present in drugs as nortriptyline hydrochloride, a white powder that is sparingly soluble in water. It is an … Nortriptyline
Products In many countries, there are no finished medicines containing amineptine on the market. Amineptin is one of the narcotics and requires an aggravated prescription. It was withdrawn from the market in France and other European countries in 1999 (Survector, Servier). Structure and properties Amineptine (C22H27NO2, Mr = 337.5 g/mol) belongs to the tricyclic antidepressants. … Amineptin
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Clomipramine is commercially available as sustained-release tablets and coated tablets (Anafranil). It has been approved in many countries since 1966 (originally Geigy, later Novartis). The injection and infusion preparations are no longer marketed. Structure and properties Clomipramine (C19H23ClN2, Mr = 314.9 g/mol) is present in drugs as clomipramine hydrochloride, a white to pale yellow … Clomipramine
