Products Cyclandelate was commercially available in many countries in the form of dragées (Cyclandelat Streuli). It was approved in 1973 and went out of commerce in 2012. Structure and properties Cyclandelate (C17H24O3, Mr = 276.4 g/mol) Effects Cyclandelate (ATC C04AX01) has vasodilator properties. It has a direct papaverine-like effect on smooth muscle, particularly that of … Cyclandelate
Products In many countries, injection solutions containing ferric carboxymaltose (Ferinject, 2007), ferrous sucrose (Venofer, 1949), ferumoxytol (Rienso, 2012), and ferric derisomaltose (ferric isomaltoside, Monofer, 2019) are commercially available. In other countries, other products with different compositions are available, for example, ferrous sodium gluconate. Iron dextrans are rarely used anymore because of the risk for severe … Iron Infusions
Products Methamphetamine is no longer registered as a drug in many countries. Pervitin has been out of commerce for some time. Methamphetamine is one of the narcotics and is subject to more stringent prescription requirements, but it is not a banned substance. In principle, medicines could be prepared in pharmacies as a magisterial prescription. In … Methamphetamine
Products Quinidine is no longer registered as a drug in many countries. Kinidine Duriles is out of commerce. Structure and properties Quinidine (C20H24N2O2, Mr = 324.4 g/mol) is present in drugs as quinidine sulfate, a white crystalline powder or fine, silky, colorless needles, which are sparingly soluble in water. Effects Quinidine (ATC C01BA01) has antiarrhythmic … Quinidine
Products Finished medicines containing fenfluramine are no longer available in many countries. Ponflural is out of commerce. Fenfluramine has also been combined with phentermine (“fen-phen”). Structure and properties Fenfluramine (C12H16F3N, Mr = 231.3 g/mol) is a fluorinated amphetamine derivative and a racemate. The pure enantiomer dexfenfluramine has also been used medicinally. Effects Fenfluramine (ATC A08AA02) … Fenfluramine
Products Injectables containing cefotaxime are no longer available in many countries Claforan is off the market. It was approved in 1981. Structure and properties Cefotaxime (C16H17N5O7S2, Mr = 455.5 g/mol) Effects Cefotaxime (ATC J01DA10) has bactericidal properties by inhibiting cell wall synthesis. Indications Bacterial infectious diseases
Products In many countries, finished drug products containing meclofenamic acid are currently no longer available. Meclomen capsules are out of stock. Structure and properties Meclofenamic acid (C14H11Cl2NO2, Mr = 296.1 g/mol) belongs to the anthranilic acid derivatives. It is structurally related to mefenamic acid (Ponstan, generics) and is present in drugs as meclofenamate sodium, a … Meclofenamic Acid
Why is the distribution of medicines discontinued? Drugs are subject to a product life cycle. They are discovered, patented, developed, approved, marketed and, in some circumstances, withdrawn from the market years to decades later. Often, distribution is discontinued due to commercial considerations. For example, the cost of approval and production exceeds the revenue from sales. … Market Withdrawal of Drugs
Products Motherwort is available as open goods in pharmacies and drugstores. Arkocaps motherwort are out of trade. Motherwort Asteraceae, motherwort. Medicinal drug Tanaceti parthenii herba – Motherwort: motherwort consists of the dried, whole or cut, aerial parts of Schultz Bip. (PhEur). PhEur requires a minimum content of parthenolide. Ingredients Sesquiterpene lactones: e.g. parthenolide. Essential oil … Motherwort
