Definition When two or more drugs are combined, they may affect each other. This is especially true with regard to their pharmacokinetics (ADME) and effects and adverse effects (pharmacodynamics). This phenomenon is called interaction and drug-drug interaction. Interactions are usually undesirable because they can lead to, for example, loss of efficacy, side effects, poisoning, hospitalization, … Interactions
Products Antibiotics (singular: antibiotic) are commercially available in the form of tablets, dispersible tablets, capsules, as infusion preparations, suspensions and syrups for children, and as granules, among others. There are also some topical preparations, such as creams, ointments, eye drops, eye ointments, ear drops, nasal ointments and sore throat tablets. The first active ingredient from … Antibiotics: Antibacterial Drugs
Products Drospirenone is commercially available as a fixed combination with ethinyl estradiol for contraception in the form of film-coated tablets (Yasmin, Yasminelle, YAZ, generics, auto-generics). Drospirenone is also used in combination with estradiol for hormone replacement therapy (Angeliq). Bayer’s originals Yasmin, Yasminelle and YAZ will go off the market in many countries in December 2021. … Drospirenone
Normal chair color Stool consists of unabsorbed food components, intestinal cells, mucus, digestive secretions, xenobiotics, bile pigments, water, and intestinal bacteria. It is usually yellow-brown to brown in color. It comes primarily from the bile pigments (bilirubin), which are metabolized by the intestinal flora to brown stercobilin, among other substances: Erythrocytes Hemoglobin Hem Biliverdin (green) … Chair Color Change
Products Nevirapine is commercially available in tablet and sustained-release tablet form (Viramune, generics). It has been approved in many countries since 1997. Structure and properties Nevirapine (C15H14N4O, Mr = 266.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. It has a non-nucleoside structure. Effects Nevirapine (ATC J05AG01) has antiviral properties … Nevirapine
Products Nicomorphine was commercially available in the form of tablets, suppositories, and as a solution for injection (Vilan). It had been approved in many countries since 1957. It was discontinued in 2015. Structure and properties Nicomorphine (C29H25N3O5, Mr = 495.5 g/mol), like heroin, is an ester as well as a nicotinic acid derivative of morphine … Nicomorphine
Products Nelfinavir was commercially available in the form of film-coated tablets (Viracept). It was approved in many countries in 1997 and withdrawn from the market in 2013 for commercial reasons. Structure and properties Nelfinavir (C32H45N3O4S, Mr = 567.8 g/mol) is present in the drug as nelfinavir mesilate, a white, amorphous powder that is sparingly soluble … Nelfinavir
Products Mefloquine is commercially available in the form of film-coated tablets (generic: mephaquine). The active ingredient was approved in many countries in 1984. Distribution of the original Lariam (Roche) was discontinued in 2014 for commercial reasons. Structure and properties Mefloquine (C17H16F6N2O, Mr = 378.3 g/mol) is a fluorinated quinoline and piperidine derivative and an analog … Mefloquine
Products Nitrendipine is commercially available in tablet form (Baypress / – mite). It was approved in many countries since 1985. In 2017, its distribution was discontinued. Structure and properties Nitrendipine (C18H20N2O6, Mr = 360.4 g/mol) is a dihydropyridine and a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. The … Nitrendipine
Products Bictegravir was approved in the United States and EU in 2018 and in many countries in 2019 in fixed combination with emtricitabine and tenofoviralafenamide in the form of film-coated tablets (Biktarvy). Structure and properties Bictegravir (C21H18F3N3O5, Mr = 449.4 g/mol) exists as a white to yellowish substance. Effects Bictegravir (ATC J05AR20) has antiviral properties. … Bictegravir
Products Canagliflozin is commercially available in the form of film-coated tablets (Invokana). It was approved in the United States and EU in 2013 and in many countries in 2014. Vokanamet is a fixed combination of canagliflozin and metformin. It was also registered in many countries in 2014. Structure and properties Canagliflozin (C24H25FO5S, Mr = 444.5 … Canagliflozin
Products Fluvastatin is commercially available in the form of capsules and sustained-release generic tablets (generics). It has been approved in many countries since 1993. Sales of the original Lescol were discontinued by Novartis in 2018. Structure and properties Fluvastatin (C24H26FNO4, Mr = 411.5 g/mol) is present in drugs as fluvastatin sodium, a white or pale … Fluvastatin
