Products Degarelix is commercially available as a powder and solvent for solution for injection (Firmagon). It was approved in many countries in February 2010. Structure and properties Degarelix is a decapeptide derived from gonadotropin-releasing hormone (GnRH), a hormone of the hypothalamus. It is present in drugs as degarelix acetate and differs from the natural substance … Degarelix
Products Ozanimod was approved in the United States and many countries in 2020 in hard capsule form (Zeposia). Structure and properties Ozanimod (C23H24N4O3, Mr = 404.5 g/mol) is present in the drug as ozanimod hydrochloride, a white solid that is highly soluble in water. Active metabolites are involved in the effects. Effects Ozanimod (ATC L04AA38) … Ozanimod
Products In many countries, there are no drugs containing dehydrochlormethyltestosterone on the market. The active ingredient was lanicized in the 1960s and distributed by the state-owned VEB Jenapharm, based in Jena, Thuringia (Oral-Turinabol tablets). Structure and properties Dehydrochloromethyltestosterone (C20H27ClO2, Mr = 334.9 g/mol) is a chlorinated derivative of methyltestosterone. Effects Dehydrochloromethyltestosterone has anabolic and androgenic … Dehydrochloromethyltestosterone
Products Ozenoxacin was approved in the United States in 2017 as a cream (Xepi). Structure and properties Ozenoxacin (C21H21N3O3, Mr = 363.4 g/mol) exists as a white to slightly yellow powder. Unlike most quinolones, it is not fluorinated. Ozenoxacin carries a pyridinyl group at position C-7. Effects Ozenoxacin has bactericidal properties and is effective against … Ozenoxacin
Products Vaginal suppositories containing dehydroepiandrosterone were registered in many countries in 2020 (Intrarosa). The active ingredient is referred to as prasterone in medications. Furthermore, an intramuscular injection solution containing the prodrug prasterone antate has been registered in many countries (Gynodian Depot). In the United States, dietary supplements (“dietary supplements”) containing dehydroepiandrosterone (DHEA) have been allowed … Dehydroepiandrosterone (DHEA)
Effects P2Y12 antagonists are antiplatelet agents and prevent the formation of blood clots. The effects are due to binding to the adenosine diphosphate receptor P2Y12 on platelets. This receptor plays a central role in glycoprotein (GP)-IIb/IIa activation and platelet aggregation. The continuous binding of adenosine diphosphate (ADP) to P2Y12 is an important prerequisite for thrombus … P2Y12 Antagonists
Products Delafloxacin was approved in the United States in 2017, in the EU in 2019, and in many countries in 2020 as a powder for a concentrate for solution for infusion and in tablet form (Quofenix). Structure and properties Delafloxacin (C18H12ClF3N4O4, Mr = 440.8 g/mol) belongs to the group of fluoroquinolones. It is present in … Delafloxacin
Products Alirocumab was approved in the United States in 2015 as the first agent in the group of PCSK9 inhibitors in the form of a solution for injection (Praluent). Evolocumab (Repatha) followed as the second agent in the EU, also in 2015. Structure and properties PCSK9 inhibitors to date are monoclonal antibodies that must be … PCSK9 Inhibitors
Products Delavirdin is commercially available in the United States under the brand name Rescriptor. It is not commercially available in many countries. Structure and properties Delavirdine (C22H28N6O3S, Mr = 456.6 g/mol) Effects Delavirdine (ATC J05AG02) is antiviral and an inhibitor of HIV reverse transcriptase. Indications HIV
Products No medicines containing delorazepam are registered in many countries. In Italy, products available include EN drops and tablets and generics. Structure and properties Delorazepam (C15H10Cl2N2O, Mr = 305.2 g/mol) is a chlorinated and demethylated diazepam (Valium) related to lorazepam (Temesta). Effects Delorazepam (ATC N05BA) has antianxiety, sedative, anticonvulsant, and sleep-inducing properties. It crosses the … Delorazepam
Products Deltamethrin is commercially available as a protector band for dogs (Scalibor). It has been approved in many countries since 2002. Structure and properties Deltamethrin (C22H19Br2NO3, Mr = 505.2 g/mol) belongs to the pyrethroids. These are synthetically produced, chemically more stable derivatives of the pyrethrins naturally occurring in certain chrysanthemums (, Dalmatian insect flower). Effects … Deltamethrin
Products Dembrexin is commercially available as a powder for administration with feed as a veterinary drug. It has been approved in many countries since 1988. Structure and properties Dembrexin (C13H17Br2NO2, Mr = 379.1 g/mol) is a benzylamine. It is structurally closely related to bromhexine (e.g., bisolvone) and ambroxol (e.g., mucosolvone) and is present in the … Dembrexin