Products Flibanserin (Addyi) was approved in the United States in 2015 in the form of film-coated tablets. The drug has not yet been registered in many countries. Flibanserin was originally developed at Boehringer Ingelheim as an antidepressant. It was marketed in the United States by Sprout Pharmaceuticals. Structure and properties Flibanserin (C20H21F3N4O, Mr = 390.4 … Flibanserin
Products The fixed combination of lidocaine and tetracaine has been commercially available as a cream in many countries since 2014 (Pliaglis). Effects Lidocaine and tetracaine (ATC N01BB52) have local anesthetic properties. The effects are due to blockade of sodium channels Indications For local anesthesia on intact skin before dermatologic procedures in adults.
Products Naloxone nasal spray was approved in the United States in 2015 (Narcan), in the EU in 2017, and in many countries in 2018 (Nyxoid). Each nasal spray contains only one dose and can be used only once. Structure and properties Naloxone (C19H21NO4, Mr = 327.37 g/mol) is a semisynthetic derivative of morphine. It is … Naloxone Nasal Spray
Products Artemether is commercially available as tablets and dispersible tablets as a fixed combination with lumefantrine (Riamet, some countries: Coartem). It has been approved in many countries since 1999. Structure and properties Artemether (C16H26O5, Mr = 298.4 g/mol) is a methyl ether dervate of the sesquiterpene artemisinin from the annual mugwort (, Qing Hao), a … Artemether
Products The fixed combination of naproxen (500 mg) with esomeprazole (20 mg) is approved in the form of coated tablets (Vimovo, AstraZeneca AG). The drug was registered in many countries in May 2011. Naproxen is contained in the core, and esomeprazole is contained in the coating of the tablet. Structure and properties Naproxen (C14H14O3, Mr … Naproxen and Esomeprazole
Products Epinephrine prefilled syringes (autoinjectors) are commercially available in many countries from various suppliers. The EpiPen has been approved since 1997 and Jext since 2010. Such syringes were originally developed for the army for the administration of antidotes to chemical weapons (e.g., ComboPen in many countries). Structure and properties Epinephrine (C9H13NO3, Mr = 183.2 g/mol) … Epinephrine Prefilled Syringe (Auto-Injector)
Products Aducanumab has been studied in phase III trials and is in the pre-approval phase. The drug is not yet commercially available. The trials were discontinued in March 2019. However, following a re-analysis, the company announced in October 2019 that it expected to file for approval. Apparently, a sufficiently high dose is required for an … Aducanumab
Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor
Products Citronella oil is commercially available in the form of sprays, bracelets, fragrance lamps and as pure essential oil, among other products. Structure and properties Citronella oil is the essential oil obtained by steam distillation from the fresh or partially dried aerial parts of (PhEur). It exists as a pale yellow to brownish yellow liquid … Citronella Oil
Products Budesonide is commercially available as a monopreparation for inhalation as a powder inhaler and suspension (Pulmicort, generics). It is also combined fixed with formoterol (Symbicort Turbuhaler, Vannair Dosage Aerosol). This article refers to monotherapy. Budesonide has been approved in many countries since 1988. Structure and properties Budesonide (C25H34O6, Mr = 430.5 g/mol) is a … Budesonide (Inhalation)
Products Bufexamac was on the market in many countries as a cream and as an ointment (Parfenac). Because the active ingredient frequently causes allergic contact dermatitis, distribution of the drugs was discontinued. Structure and properties Bufexamac or 2-(4-butoxyphenyl)–hydroxyacetamide (C12H17NO3, Mr = 223.3 g/mol) is a white to almost white crystalline powder that is practically insoluble … Bufexamac
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
