Products Ketanserin is commercially available as a gel (Vulketan). It has been approved in many countries since 1995 and exclusively as a veterinary drug. In other countries, it is also available for human use as an antihypertensive. Structure and properties Ketanserin (C22H22FN3O3, Mr = 395.4 g/mol) is a quinazolinone derivative. Ketanserin hydrogenotartrate is used in … Ketanserin
Products Erenumab (Aimovig) was the first agent from the group of CGRP inhibitors to be approved in 2018. Fremanezumab (Ajovy) and galcanezumab (Emgality) followed. Structure and properties CGRP inhibitors are humanized or human monoclonal IgG antibodies directed against calcitonin gene-related peptide (CGRP). Low-molecular-weight CGRP receptor antagonists (so-called Gepante) are in clinical development. Some agents have … CGRP Inhibitors
Products Reserpine was commercially available in many countries in the form of dragées as a fixed combination with dihydroergocristin and clopamide (Brinerdin, off label). Structure and properties Reserpine (C33H40N2O9, Mr = 609 g/mol) exists as a crystalline powder or as small, white to faint yellow crystals that slowly darken under the influence of light. The … Reserpine
Products Hemp and preparations made from it, such as marijuana, cannabis resin, THC, and cannabis extracts, are generally among the prohibited narcotics in many countries. However, the Federal Office of Public Health may grant exemptions for research, drug development and limited medical use. In 2013, a cannabis oral spray (Sativex) was approved as a medicine … Cannabis
Products Macitentan is commercially available in the form of film-coated tablets (Opsumit). It was approved in the United States in October 2013 and in many countries in 2014. Macitentan was launched as a successor to bosentan (Tracleer) as it loses patent protection. Structure and properties Macitentan (C19H20Br2N6O4S, Mr = 588.3 g/mol) is a brominated pyrimidine … Macitentan
Products Nifedipine is commercially available in the form of sustained-release tablets (generics). It was first approved in the mid-1970s. Sales of the original Adalat were discontinued in many countries in 2019. Structure and properties Nifedipine (C17H18N2O6, Mr = 346.3 g/mol) is a dihydropyridine. It exists as a yellow crystalline powder that is practically insoluble in … Nifedipine: Drug Effects, Side Effects, Dosage and Uses
Products Isosorbide dinitrate is commercially available in many countries in the form of tablets, sustained-release tablets, sustained-release capsules, as an infusion concentrate, and as a spray (Isoket). The drug first came on the market in the 1940s. Structure and properties Isosorbide dinitrate (C6H8N2O8, Mr = 236.14 g/mol) exists as a white, fine, crystalline and odorless … Isosorbide Dinitrate
Products Isosorbide mononitrate was commercially available in the form of divisible extended-release tablets (Corangin). It was approved in many countries in 1987 and was withdrawn from the market in 2014. Other nitrates can be used as substitutes, such as isosorbide dinitrate. Structure and properties Isosorbide mononitrate (C6H9NO6, Mr = 191.1 g/mol) is an organic nitrate. … Isosorbide Mononitrate
Products No finished drug products containing tolazoline are on the market in many countries. Structure and properties Tolazoline (C10H12N2, Mr = 160.2 g/mol) Effects Tolazoline (ATC C04AB02, ATC M02AX02) is α-sympatholytic and vasodilatory.
Products Nebivolol is commercially available in tablet form as a monopreparation (Nebilet, generic, USA: Bystolic) and in combination with hydrochlorothiazide (Nebilet plus). The active ingredient has been approved in many countries since 1998. A fixed combination with valsartan is also available in some countries (Byvalson). Structure and properties Nebivolol (C22H25F2NO4, Mr = 405.4 g/mol) has … Nebivolol
Products Alcohol is contained in numerous intoxicating and stimulant products, such as wines, sparkling wines, beers and high-proof spirits. Per capita consumption in many countries averages about 8 liters of pure alcohol per year. Ethanol is also available as an open product in various qualities in pharmacies and drugstores (e.g. ethanol 70% with camphor, ethanol … Ethanol
Products Sildenafil is commercially available in the form of film-coated tablets and as a solution for injection (Viagra, Revatio, generics). It has been approved in many countries since 1998. Generics went on sale July 22, 2013, and the patent expired June 21. Pfizer launched auto-generic sildenafil Pfizer, identical to the original, back in May. In … Sildenafil
