Products Nitric oxide is commercially available as a gas for medical use (inhalation gas). It has been approved since 1999. Structure and properties Nitric oxide (NO, Mr = 30.0 g/mol) exists as a colorless gas that turns brown in air. It is a free radical. Nitrogen dioxide forms rapidly in air. Structure: -N=O Effects Nitric … Nitric Oxide
Products Phosphodiesterase-5 inhibitors are commercially available in the form of film-coated tablets and meltable tablets. Sildenafil (Viagra) was the first active ingredient from this group to be approved in the United States, the EU, and many countries in 1998. Generics are also available today. Sildenafil was originally to be developed by Pfizer for the treatment … Phosphodiesterase-5 Inhibitors
Products Alpha blockers are available in many countries in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. The most commonly prescribed today is tamsulosin (Pradif T, generic). Alpha blocker is short for alpha1-adrenoreceptor antagonist. Structure and properties The first alpha blockers-alfuzosin, doxazosin, and terazosin-were developed as derivatives of quinazoline: Effects Alpha blockers (ATC … Alpha Blocker
Products Iloprost is commercially available as an infusion solution concentrate and as a solution for nebulizers (Ilomedin, Ventavis). It has been approved in many countries since 2005. Structure and properties Iloprost (C22H32O4, Mr = 360.5 g/mol) is an analog of prostacyclin. It is present in drugs as iloprosttrometamol, an oily substance that is sparingly soluble … Iloprost
Products The fixed combination of the neprilysin inhibitor sacubitril with valsartan was approved in the United States, the EU, and many countries in 2015 in the form of film-coated tablets (Entresto). The combination is also referred to as LCZ696. Structure and properties Sacubitril (C24H29NO5, Mr = 411.5 g/mol) is an ester prodrug that is hydrolyzed … Sacubitril
Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil
Products Buphenin was included in Arbid drops in combination with diphenylpyralin until late 2011. Structure and properties Buphenin (C19H25NO2, Mr = 299.41 g/mol), like other sympathomimetics, has structural similarity to catecholamines, for example, epinephrine. Effects Buphenine (ATC C04AA02) is β-sympathomimetic and thus vasodilatory and positively inotropic. Indications No longer commercially available in many countries for … Buphenin
