Diseases that cause weight gain by increasing tissue (such as fat):
Endocrine, nutritional, and metabolic disorders (E00-E90).
- Obesity (overweight)
- Cushing’s syndrome – disease caused by an excess of glucocorticoids.
- Hyperalimentation (overeating)
- Hypothyroidism (underactive thyroid gland)
- Menopause (menopause in women)
- Polycystic ovary syndrome (synonyms: PCOS; polycystic ovary syndrome; polycystic ovary syndrome; polycystic ovary syndrome; polycystic ovary syndrome; polycystic ovaries; polycystic ovary disease; polycystic ovary syndrome (PCO syndrome); polycystic ovary syndrome; Stein-Leventhal syndrome; ICD-10 E28. 2: Polycystic ovary syndrome) – symptom complex characterized by hormonal dysfunction of the ovaries (ovaries).
Neoplasms – tumor diseases (C00-D48).
- Hormone-producing pituitary tumors – neoplasms in the area of the pituitary gland that produce hormones.
- Insulinoma – in the majority of cases benign neoplasm in the area of the pancreas (pancreas).
- Tumors leading to a hypothalamic lesion (hypothalamus is part of the diencephalon (interbrain) and serves as the top regulatory center)
Psyche – Nervous System (F00-F99; G00-G99).
- Depression
- Stress/severe stress
Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99)
- Ascites (abdominal fluid)
Medication
- Antidepressants
- Monoamine oxidase inhibitors (MAO inhibitors) – moclobemide
- Noradrenergic and specific serotonergic antidepressants (NaSSA) – mirtazapine (moderate).
- Selective serotonin–norepinephrine reuptake inhibitors (SSNRIs) – duloxetine (moderate), venlafaxine (moderate).
- Selective serotonin reuptake inhibitors (SSRI) – citalopram (moderate), escitalopram (moderate), fluoxetine (low), fluvoxamine, paroxetine (moderate), sertraline (moderate).
- Tetracyclic antidepressants (maprotiline, mianserine).
- Tricyclic antidepressants (TCAs) – amitriptyline, clomipramine, doxepin, imipramine, nortriptyline, opipramol, trimipramine.
- Antiepileptic drugs
- AMPA receptor antagonist (perampanel).
- KCNQ2/3 opener (retigabine).
- Classical antiepileptic drugs (valproate).
- Antihistamines (ketotifen).
- Antipsychotics (neuroleptics)
- Amisulpride, aripiprazole, clozapine, haloperidol, melperone, olanzapine (strong), quetiapine, risperidone (moderate), ziprasidone (low), zuclopenthixol.
- Alimemazine, chlorpromazine (strong), perphenazine, promethazine (moderate), promazine (mild), thioridazine,triflupromazine,
- Hormones
- Anabolic steroids (strong)
- Androgens: testosterone and androstenedione (medium).
- Cortisol and its derivatives (strong)
- Progestogens (chlormadinone acetate, cyproterone acetate, desogestrel, dienogest, drospirenone, gestodene, levonorgestrel, norethisterone, norgestimate, nomegestrol) (very low).
- GnRH analogues (goserelin acetate, leuporelin acetate, buderelin acetate, nafarelin acetate, triptorelin acetate).
- Insulin (strong)
- Contraceptives: ethinyl estradiol (low).
- Estrogens, except ethinyl estradiol (very low).
- Pizotifen
- Phase prophylactics
- Lithium, valproate (strong), carbamzepine (moderate), gabapentin, lamotrigine, topiramate (low).
- Other pharmaceuticals with adipogenic effects
- Alpha-2 agonists (α2-adrenoceptor agonists) (very low) such as midodrine.
- Beta-blockers (low): nonselective beta-blockers (eg, carvedilol, propranolol, soltalol) [inhibition of insulin secretion; more potent than selective beta-blockers]; selective beta-blockers (eg, atenolol, bisoprolol, metoprolol)
- Glinides (nateglinide, repaglinide).
- Glitazones (thiazolidinediones: pioglitazone, rosiglitazone).
- Sulfonylureas (medium) (glibenclamide, gliclazide, glimepiride, gliquidone, tolbutamide).
- Thiazolidinediones (low) such as rosiglitazone.
Further
- Alcohol excess
- Limitation of mobility due to physical and mental reasons (e.g., apoplexy/stroke)
- Pregnancy
Diseases that cause weight gain due to edema (eg.B. heart failure/cardiac insufficiency, renal failure, liver failure) lead to – see under differential diagnosis to edema.