Products
Ceftibuten was commercially available in many countries as a powder for preparation of a suspension and in capsule form (Cedax). It had been approved in many countries since 1994.
Structure and properties
Ceftibuten (C15H14N4O6S2, Mr = 410.4 g/mol) is present in drugs anhydrous or as ceftibutene dihydrate.
Effects
Ceftibuten (ATC J01DA39) has bactericidal properties against Gram-positive and Gram-negative pathogens. The effects are based on inhibition of bacterial cell wall synthesis.
Indications
For the treatment of bacterial infectious diseases:
- Infections of the upper and lower respiratory tract
- Urinary tract infections
Dosage
According to the professional information. The drug is usually taken once a day fasting. The usual duration of therapy is five to ten days.
Contraindications
Ceftibuten is contraindicated in case of hypersensitivity. Full precautions can be found in the drug label.
Interactions
Drug-drug interactions have been described with vitamin K antagonists.
Adverse effects
The most common possible adverse effects include gastrointestinal symptoms such as nausea, diarrhea, and headache. As with other beta-lactam antibiotics, hypersensitivity reactions may occur, occasionally progressing to anaphylaxis.
