Products Temozolomide is commercially available as capsules and as a powder for the preparation of an infusion solution (Temodal, generics). It has been approved in many countries since 1999. Structure and properties Temozolomide (C6H6N6O2, Mr = 194.2 g/mol) is an imidazotetrazine derivative. It is a prodrug that is biotransformed by hydrolysis to the active metabolite … Temozolomide
Products Streptozocin is no longer commercially available in many countries. Zanosar is no longer available. Structure and properties Streptozocin (C8H15N3O7, Mr = 265.2 g/mol) is a -nitrosourea. Effects Streptozocin (ATC L01AD04) is cytotoxic. Indications For the treatment of metastatic pancreatic islet cell carcinoma.
Products Tioguanine is commercially available in tablet form (Lanvis). It has been approved in many countries since 1973. Structure and properties Tioguanine (C5H5N5S, Mr = 167.2 g/mol) is a 6-thiol analog of guanine. Effects Tioguanine (ATC L01BB03) has cytotoxic properties as a purine antimetabolite. Indications For the treatment of acute myeloid leukemia. Other indications include … Tioguanin
Products Treosulfan was approved in the EU in 2019 and in many countries in 2020 as a powder for the preparation of an infusion solution (Trecondi). Structure and properties Treosulfan (C6H14O8S2, Mr = 278.3 g/mol) Effects Treosulfan (ATC L01AB02) has cytotoxic and antineoplastic properties. It is a prodrug of a bifunctional alkylating agent active against … Treosulfan
Products Epirubicin is commercially available as a concentrate for injection/instillation (farmorubicin, generics). It has been approved in many countries since 1993. Structure and properties Epirubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to doxorubicin. Effects Epirubicin (ATC L01DB03) is antineoplastic. It is an anthracycline antibiotic, rapidly penetrates the cell, binds to DNA, and … Epirubicin
Products Docetaxel is commercially available as an infusion preparation (Taxotere, generics). It was approved in many countries in 1996 as a second taxane after paclitaxel (Taxol). Structure and properties Docetaxel (C43H53NO14, Mr = 807.9 g/mol) is present in the drug as docetaxel trihydrate, a white powder that is practically insoluble in water. The lipophilic drug … Docetaxel
Products Paclitaxel is commercially available as an infusion concentrate (Taxol, generic). It has been approved in many countries since 1993. The active ingredient itself is also known as taxol. Protein-bound nab-paclitaxel (Abraxane) was approved in many countries in 2014. Structure and properties Paclitaxel (C47H51NO14, Mr = 853.9 g/mol) is a complex tetracyclic diterpene. It exists … Paclitaxel
Products Irinotecan is commercially available as an infusion concentrate (Campto, generic). It has been approved in many countries since 1998. In 2017, the nanoliposomal formulation irinotecan sucrosofate was released (Onivyde). Structure and properties Irinotecan (C33H38N4O6, Mr = 586.7 g/mol) is a semisynthetic derivative of camptothecin, a plant alkaloid derived from the tree. In the drug … Irinotecan
Products Irinotecansucrosofate was approved in many countries in 2017 as a concentrate for the preparation of an infusion solution (Onivyde). Structure and properties Irinotecansucrosofate is a nanoliposomal formulation of irinotecan. The drug is present enclosed in liposomes and therefore has a much longer half-life than irinotecan. The formulation may also contribute to lower toxicity and … Irinotecansucrosofate
Products Cisplatin is available as an infusion concentrate. Several generic products are available in many countries. Platinol is out of commerce. Structure and properties Cisplatin (PtCl2(NH3)2, Mr = 300.1 g/mol) or -diammine dichloroplatinum(II) exists as a yellow powder or as orange-yellow crystals and is sparingly soluble in water. It is an inorganic heavy metal complex … Cisplatin
Products Bortezomib is commercially available as a lyophilizate for the preparation of a solution for injection (Velcade). It has been approved in many countries since 2005. Generic versions were registered in 2018. Structure and properties Bortezomib (C19H25BN4O4, Mr = 384.2 g/mol) is a dipeptidyl derivative of boric acid. Effects Bortezomib (ATC L01XX32) has cytotoxic and … Bortezomib
Products Bendamustine is commercially available as a lyophilizate for the preparation of an infusion solution (ribomustine). It actually has good oral bioavailability when taken fasting, but is only administered parenterally. Generic drugs are registered. Bendamustine was developed in 1963 by Ozegowski et al. in Jena in what was then East Germany and was marketed only … Bendamustine
