Products Mitoxantrone is commercially available as an infusion/injection solution (Novantrone, generic). It has been approved in many countries since 1985. Structure and properties Mitoxantrone (C22H28N4O6, Mr = 444.5 g/mol) Effects Mitoxantrone (ATC L01DB07) has cytotoxic and immunosuppressive properties. The effects are due to inhibition of topoisomerase II and intercalation of DNA. Indications Carcinomas, lymphomas, leukemia … Mitoxantrone
Products Vinblastine is commercially available as an injectable (Velbe). It has been approved in many countries since 1961. Structure and properties Vinblastine is present in drugs as vinblastine sulfate (C46H60N4O13S, Mr = 909 g/mol) is present, a white to slightly yellowish, very hygroscopic powder that is readily soluble in water. It is a vinca alkaloid … Vinblastine
Products Idarubicin is commercially available in capsule form and as a solution for injection (Zavedos, generics). It has been approved in many countries since 1992. Structure and properties Idarubicin (C26H27NO9, Mr = 497.5 g/mol) Effects Idarubicin (ATC L01DB06) is a cytotoxic anthracycline antibiotic. It inhibits topoisomerase II by intercalation into DNA, thereby inhibiting nucleic acid … Idarubicin
Products Doxorubicin is commercially available as an injectable (Adriblastin, generic). It has been approved in many countries since 1989. Caelyx is a pegylated and liposomal formulation of the drug and was registered in 1997. Myocet is a liposomal and nonpegylated formulation. Structure and properties Doxorubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to … Doxorubicin
Products Fludarabine is commercially available as an injection/infusion preparation (generic, original: Fludara). It was approved in the United States in 1991 and in many countries in 1995. Structure and properties Fludarabine (C10H12FN5O4, Mr = 285.2 g/mol) or 9-β-D-arabinosyl-2-fluoroadenine is present in drugs as fludarabine phosphate, a white, crystalline, hygroscopic powder that is sparingly soluble in … Fludarabine
Products Clofarabine is commercially available as a concentrate for the preparation of an infusion solution (Evoltra). The drug is not registered in many countries. Structure and properties Clofarabine (C10H11ClFN5O3, Mr = 303.7 g/mol) is a purine derivative. Effects Clofarabine (ATC L01BB06) is antitumoral and cytotoxic. Indications Acute lymphoblastic leukemia (ALL) in pediatric patients.
Products Oxaliplatin is commercially available as an infusion concentrate (Eloxatin, generic). It was approved in many countries in 2000 as a third platinum compound for cancer therapy. Structure and properties Oxaliplatin (C8H14N2O4Pt, Mr = 397.3 g/mol) is a platinum compound. It exists as a white crystalline powder and is sparingly soluble in water. Effects Oxaliplatin … Oxaliplatin
Products Chlorambucil is commercially available in the form of film-coated tablets (Leukeran). It has been approved in many countries since 1957. Structure and properties Chlorambucil (C14H19Cl2NO2, Mr = 304.2 g/mol) is an aromatic nitrogen-lost derivative. It exists as a white crystalline powder that is practically insoluble in water. The effects are due to the active … Chlorambucil
