Lupus
Systemic lupus erythematosus (SLE) is a collagenosis. It is characterized by inflammatory reactions in the entire body, which can be in acute or chronic phases. In addition to the systemic form, there are others that are restricted to the skin.
Autoantibodies, so-called ANA (antinuclear antibodies) and an increased number of inflammatory cells can be detected in the blood of those affected. These mistakenly attack the body’s own cells. The antibodies in lupus erythematosus are not directed against a specific organ, but against every cell in the body.
In addition to the skin, the heart, kidneys, lungs and the nervous system as well as joints can be affected. The female sex is ten times more likely to be affected. The onset of the disease is possible at any age, but is more common between the ages of 20 and 40.
Triggers include environmental and genetic factors as well as certain drugs. The symptoms are organ-dependent. Those affected complain of fatigue, increased body temperature, joint pain, gastrointestinal complaints and inflammatory changes in the skin and mucous membranes, among other things.
Inflammation of the pericardium and pulmonary pleura also occurs. The majority of cases develop a so-called butterfly erythema, a red skin rash, on the face. The respective therapy depends on the organ involvement and is usually symptomatic. The overreaction of the immune system is also reduced with the help of immunosuppressive drugs.
