Membranoproliferative Glomerulonephritis: Medical History

Medical history (history of illness) represents an important component in the diagnosis of membranoproliferative glomerulonephritis.

Family history

Social history

Vegetative anamnesis

  • Increase in weight
  • Changes in the body (bloated)
  • Changes in the urine
  • Symptoms such as headaches, which may indicate hypertension (high blood pressure)

Self history including medication history.

  • Pre-existing conditions
  • Presence of malignant (malignant) diseases.
  • Operations

Medications (nephrotoxic – drugs that damage the kidneys/nephrotoxic drugs).

  • ACE inhibitors and AT1- receptor antagonists (drugs used to treat hypertension; side effects – acute: decrease in glomerular filtration rate (GFR), associated with a rise in creatinine: ACE inhibitors as well as AT1-receptor antagonists abolish vasoconstriction in the vas efferens, and a decrease in GFR and a rise in serum creatinine result. Up to 0.1 to 0.3 mg/dl, this is usually tolerable. However, in the presence of hemodynamically relevant renal artery stenosis (not uncommon in patients with atherosclerosis/arteriosclerosis/arteriosclerosis), GFR becomes markedly angiotensin II-dependent, and administration of an ACE inhibitor or AT1 receptor antagonist may result in acute renal failure/ANV)!
  • Antiphlogistic and antipyretic analgesics (analgesics; nonsteroidal anti-inflammatory drugs (NSAID), nonsteroidal anti-inflammatory drugs) and nonsteroidal anti-inflammatory drugs (NSAIDs), respectively, such as:
    • Acetylsalicylic acid (ASA).
    • Diclofenac
    • Ibuprofen/naproxen
    • Indometacin
    • Metamizole or novaminsulfone is a pyrazolone derivative and analgesic from the group of non-acidic non-opioid analgesics (highest analgesic and antipyretic activity. Side effects: Circulatory fluctuations, hypersensitivity reactions, and very rarely agranulocytosis.
    • Paracetamol
    • Phenacetin (phenacetin nephritis)
  • Selective COX-2 inhibitors such as rofecoxib, celecoxib (side effects: decreased sodium and water excretion, blood pressure increase and peripheral edema. This is usually accompanied by hyperkalemia (excess potassium)!)
  • Antibiotics such as:
  • Antivirals (drugs that inhibit the action of viruses) such as:
    • Aciclovir
    • Cidofovir
    • Foscarnet
    • Ganciclovir
    • Valaciclovir
  • Amphotericin B
  • Allopurinol
  • Ciclosporin (cyclosporin A)
  • Colchicine
  • D-Penicillamine
  • Gold
  • Interferon