Sorivudine: Effects, Uses & Risks

Sorivudine is a medical drug that was developed in Japan to treat herpes. Sorivudine was marketed under the trade name Usevir and has been unavailable since a drug scandal killed several people in Japan. It did not even receive approval in Europe, so the drug did not have to be withdrawn from the market. What … Sorivudine: Effects, Uses & Risks

5-Fluorouracil

Products 5-Fluorouracil is commercially available as an ointment (Efudix), as a topical solution in combination with salicylic acid (Verrumal), and in preparations for parenteral administration. This article refers to topical application. In 2011, 5-fluorouracil at the lower concentration of 0.5% was approved in many countries with Actikerall. Structure and properties 5-Fluorouracil (C4H3FN2O2, Mr = 130.08 … 5-Fluorouracil

Benfotiamine

Products Benfotiamine is commercially available in Germany in the form of film-coated tablets, among others. It is usually combined fixed with vitamin B6 (pyridoxine). In many countries, benfotiamine is not registered. Structure and properties Benfotiamine (C19H23N4O6PS, Mr = 466.4 g/mol) is a lipophilic prodrug of thiamine (vitamin B1). It is dephosphorylated in the intestine to … Benfotiamine

Thiamine (Vitamin B1)

Products Thiamine (vitamin B1) is commercially available in tablet form and as a solution for injection (e.g., Benerva, Neurorubin, generics), among others. It is a component of numerous combination preparations (e.g., Berocca). Structure and properties Thiamine (C12H17N4OS+, Mr = 265.4 g/mol) is usually present in drugs as thiamine nitrate or thiamine hydrochloride. Thiamine hydrochloride, unlike … Thiamine (Vitamin B1)

Capecitabine

Products Capecitabine is commercially available in the form of film-coated tablets (Xeloda, generic). It has been approved in many countries since 1998. Structure and properties Capecitabine (C15H22FN3O6, Mr = 359.4 g/mol) is a prodrug and is converted to the cell-toxic 5-fluorouracil, the active drug, in a three-step process. Capecitabine exists as a white crystalline powder … Capecitabine

Brivudine

Products Brivudine is commercially available in tablet form (Brivex). It has been approved in many countries since 2003. It was originally developed in the German Democratic Republic. Structure and properties Brivudine (C11H13BrN2O5, Mr = 333.1 g/mol) is a nucleoside analog related to thymidine. Effects Brivudine (ATC J05AB) has antiviral properties against herpes viruses. It inhibits … Brivudine

Pancreatic Cancer Causes and Treatment

Symptoms Symptoms of pancreatic cancer include: Jaundice, light-colored stools, dark urine, and itching due to narrowing of the bile duct (cholestasis) Upper abdominal pain, tumor pain Indigestion, lack of appetite, weight loss, muscle wasting, feeling full, nausea, vomiting, diarrhea. Fatigue, weakness Inflammation of the pancreas, dysglycemia. Thrombosis In addition, there are the adverse effects of … Pancreatic Cancer Causes and Treatment

Actinic Keratosis Treatment

Symptoms Actinic keratosis is a skin disease that manifests itself in various forms. Pink or brown, scaly, highly keratinized patches or papules often form on a reddened base, with sizes ranging from millimeters to centimeters. The lesions can occur all over the body, but usually affect sun-exposed areas such as the head, bald head, ears, … Actinic Keratosis Treatment

Basal Cell Carcinoma

Symptoms Basal cell carcinoma (basal cell carcinoma) is a light skin cancer, which presents differently and is most common in older people. It is the most common cancer in fair-skinned people. The skin lesion usually grows slowly and may manifest itself, for example, as a waxy, translucent and pearly nodule with dilated blood vessels (telangiectasia) … Basal Cell Carcinoma

Irinotecansucrosofate

Products Irinotecansucrosofate was approved in many countries in 2017 as a concentrate for the preparation of an infusion solution (Onivyde). Structure and properties Irinotecansucrosofate is a nanoliposomal formulation of irinotecan. The drug is present enclosed in liposomes and therefore has a much longer half-life than irinotecan. The formulation may also contribute to lower toxicity and … Irinotecansucrosofate

Colon Cancer: Causes and Treatment

Symptoms The possible initial symptoms of colon cancer include: Change in bowel habits, diarrhea or constipation. Bleeding, blood in the stool, black colored stool. Frequent urge to defecate, discharge of small and thin portions. Abdominal pain, flatulence, cramps. Weight loss, weakness, anemia Because the cancer grows slowly, it takes years before clinical symptoms finally appear. … Colon Cancer: Causes and Treatment