Products Numerous nasal sprays containing vasoconstrictive agents are commercially available. Among the best known are xylometazoline (Otrivin, generic) and oxymetazoline (Nasivin). In addition to sprays, nasal drops and nasal gels are also available. Decongestants for the nose have been available since the early 20th century (Sneader, 2005). As early as the 1940s, rhinitis medicamentosa was … Decongestant Nasal Sprays
Effects Antihistamine nasal sprays have antihistamine and antiallergic properties. They are antagonists of histamine at the H1 receptor, reversing histamine effects and thus relieving symptoms such as sneezing, itching, and runny nose. Azelastine is also mast cell stabilizing, which is considered a therapeutic advantage. Glucocorticoid nasal sprays are more effective than antihistamine nasal sprays, but … Antihistamine Nasal Sprays
Products Xylometazoline is commercially available in the form of nasal sprays and as nasal drops (Otrivin, generics, combination products, for example with dexpanthenol). It was developed at Ciba and has been approved in many countries since 1958. Structure and properties Xylometazoline is present in drugs as xylometazoline hydrochloride (C16H24N2 – HCl, Mr = 280.8 g/mol), … Xylometazoline
Products Triamcinolone acetonide nasal sprays have been approved in many countries since 1996 and are commercially available as propellant-free metered-dose sprays (Nasacort, Nasacort Allergo, Suspension). Structure and properties Triamcinolone acetonide (C24H31FO6, Mr = 434.5 g/mol) is a white crystalline powder that is practically insoluble in water. It is a lipophilic and potent derivative of triamcinolone. … Triamcinolone Acetonide Nasal Spray
Products Tixocortolpivalate is commercially available in combination with neomycin as a nasal spray (Pivalone). It has been approved in many countries since 1986. Structure and properties Tixocortolpivalate (C21H30O4S, Mr = 378.5 g/mol) is a 21-thiosteroid. Effects Tixocortolpivalate (ATC R01AD07) has anti-inflammatory and antiallergic properties. The effects are due to binding to intracellular glucocorticoid receptors. Indications … Tixocortolpivalate
Products Nasal sprays containing beclomethasone dipropionate have been approved in many countries since 1998 (Otri Hay Fever, formerly Beconase). Structure and properties The active ingredient beclometasone is present in the drug as beclometasone dipropionate (C24H32O4, Mr = 384.5 g/mol) is present, a white crystalline powder that is practically insoluble in water. Effects Beclomethasone dipropionate (ATC … Beclometasone Nasal Spray
Products Humidifying nasal sprays are commercially available from a variety of suppliers (e.g., Fluimare, Nasmer, Triomer, Emser Nasal Spray). Ingredients The solutions in the sprays usually contain one of the following salts: Sodium chloride (table salt) Sea salt with various minerals and trace elements. Emser salt with various minerals and trace elements In addition, active … Humidifying Nasal Sprays
Products Levocabastine is commercially available as eye drops and as a nasal spray (Livostin). It has been approved in many countries since 1992. See also under levocabastine eye drops. Structure and properties Levocabastine (C26H29FN2O2, Mr = 420.52 g/mol) is a substituted cyclohexylpiperidine derivative. In medicinal products, levocabastine hydrochloride, which is practically insoluble in water, is … Levocabastine: Drug Effects, Side Effects, Dosage and Uses
Products Tuaminoheptane is commercially available in combination with acetylcysteine in the form of a nasal spray (rinofluimucil). It has been approved in many countries since 1990. Structure and properties Tuaminoheptane (C7H17N, Mr = 115.2 g/mol) is a primary amine. Effects Tuaminoheptane (ATC R01AA11, ATC R01AB08) has sympathomimetic, vasoconstrictor, and decongestant properties. It facilitates breathing and … Tuaminoheptane
Products Budesonide nasal sprays have been approved in many countries since 1995 (Cortinasal, generic). Rhinocort nasal spray has not been marketed since 2018. Sales of the Rhinocort turbuhaler were discontinued in 2020. Structure and properties Budesonide (C25H34O6, Mr = 430.5 g/mol) is a racemate and exists as a white, crystalline, odorless, tasteless powder that is … Budesonide Nasal Spray
