Schmidt Syndrome: Causes, Symptoms & Treatment

Schmidt syndrome is also known as polyendocrine autoimmune syndrome type II. It is an autoimmune disorder associated with multiple endocrine gland insufficiencies. What is Schmidt syndrome? Schmidt syndrome was originally described by pathologist Martin Benno Schmidt as a combination of Addison’s disease and Hashimoto’s thyroiditis. Hashimoto’s thyroiditis is a chronic inflammation of the thyroid gland … Schmidt Syndrome: Causes, Symptoms & Treatment

Conn Syndrome

Definition-What is Conn syndrome? Conn syndrome, also known as primary hyperaldosteronism, is caused by a pathological change in the adrenal cortex, which leads to an overproduction of the messenger substance aldosterone. Aldosterone is a hormone which has an important function in the regulation of the human salt and water balance. It sometimes plays a decisive … Conn Syndrome

I recognize Conn syndrome from these symptoms | Conn Syndrome

I recognize Conn syndrome from these symptoms The main symptoms of Conn syndrome are therapy-resistant high blood pressure and a low blood potassium level. High blood pressure can lead to headache and dizziness. Furthermore, sleep disturbances, tiredness, nervousness and concentration problems can be observed in those affected. The low potassium content, a so-called hypokalemia, can … I recognize Conn syndrome from these symptoms | Conn Syndrome

Aliskiren

Products Aliskiren is commercially available in the form of film-coated tablets (Rasilez, Rasilez HCT + hydrochlorothiazide). It was approved in many countries, in the EU and in the United States in 2007 (Other brand name: Tekturna). Note: Other combination preparations, e.g., with amlodpine (Rasilamlo), are no longer available. Structure and properties Aliskiren (C30H53N3O6, Mr = … Aliskiren

Spironolactone

Products Spironolactone is commercially available in film-coated tablet form as a monopreparation (Aldactone) and in fixed combination with furosemide (Furospir). It was developed in the 1950s at G.D. Searle in Chicago and approved in 1959, and in many countries in 1961. Structure and properties Spironolactone (C24H32O4S, Mr = 416.6 g/mol) exists as a white to … Spironolactone

Metyrapon

Products Metyrapone is commercially available in the form of capsules (Metopiron). It has been approved in many countries since 1961. Structure and properties Metyrapone (C14H14N2O, Mr = 226.27 g/mol) is a pyridine derivative. It is a white to light amber crystalline powder that is sparingly soluble in water. Effects Metyrapone (ATC V04CD01) inhibits the synthesis … Metyrapon

Saponins: Function & Diseases

Saponins are soap-like compounds which are formed only in plants. The individual molecules consist of a hydrophilic and a lipophilic portion. Their structures, properties and modes of action are very diverse. What are saponins? Saponins are biological compounds formed exclusively in plant tissues. They represent secondary plant compounds. Furthermore, they are subject to a great … Saponins: Function & Diseases

Hyperkalemia (High Potassium)

Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hyperkalemia (High Potassium)

Hypokalemia (Low Potassium)

Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hypokalemia (Low Potassium)