antidopaminergic

Risperidone: Drug Effects, Side Effects, Dosage and Uses

Products Risperidone is commercially available as film-coated tablets, meltable tablets, an oral solution, and a suspension for intramuscular administration (Risperdal, generics). The active ingredient has been approved in many countries since 1994. Structure and properties Risperidone (C23H27FN4O2, Mr = 410.5 g/mol) exists as a white powder that is practically insoluble in water. It is a … Risperidone: Drug Effects, Side Effects, Dosage and Uses

Promethazine

Products In many countries, drugs containing promethazine are currently no longer on the market. The last product to be withdrawn from the market was Rhinathiol promethazine with the expectorant carbocisteine on January 31, 2009. However, medicines are still available in many countries. The original drug is Phenergan. Promethazine was developed in the 1940s at Rhône-Poulenc, … Promethazine

Clotiapine

Products Clotiapine is commercially available in tablet form (Entumin). It has been approved in many countries since 1967. Structure and properties Clotiapine (C18H18ClN3S, Mr = 343.87 g/mol) is a dibenzothiazepine. The structurally closely related neuroleptic quetiapine (Seroquel) also belongs to this group of drugs. Effects Clotiapine (ATC N05AH06) has adrenolytic, antidopaminergic, anticholinergic, antihistamine, sedative, psychomotor … Clotiapine

Ondansetron

Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron

Penfluridol

Products Penfluridol is no longer available as a drug in many countries. Semap tablets are out of commerce. Structure and properties Penfluridol (C28H27ClF5NO, Mr = 523.96 g/mol) is a diphenylbutylpiperidine. Effects Penfluridol (ATC N05AG03) is potent antidopaminergic, antiemetic, and potent antipsychotic against hallucinations and delusions. It has minimal activity at the 5-HT2 receptor (antiserotonergic) and … Penfluridol

Perphenazine

Products Perphenazine was commercially available in the form of film-coated tablets (Trilafon). It was approved in many countries in 1957 and went out of commerce on 3/31/2013. Structure and properties Perphenazine (C21H26ClN3OS, Mr = 403.9 g/mol) is a piperidine derivative of phenothiazine. It exists as a white to yellowish white crystalline powder that is practically … Perphenazine

Asenapine

Products Asenapine is commercially available in the form of sublingual tablets (Sycrest). It was approved in many countries in 2012. In the United States, it has been registered since 2009. Structure and properties Asenapine (C17H16ClNO, Mr = 285.8 g/mol) is present in the drug as asenapine maleate. It belongs to the class of dibenzooxepin pyrroles. … Asenapine

Diphenylbutylpiperidine

Effects Diphenylbutylpiperidines are antidopaminergic, antipsychotic, and antiemetic. Mechanism of action Dopamine antagonists Indications Clinical pictures of the schizophrenic type. Structure and properties Derivatives of diphenylbutylpiperidine. Active ingredients Penfluridol (Semap, off label). Fluspirilen (IMPA, D) Pimozide (out of commerce)

Droperidol

Products Droperidol is commercially available as a solution for injection (Droperidol Sintetica). It has been approved in many countries since 2006. Structure and properties Droperidol (C22H22FN3O2, Mr = 379.4 g/mol) structurally belongs to the butyrphenones and exists as a white powder that is practically insoluble in water. It is a benzimidazolinone derivative. Effects Droperidol (ATC … Droperidol

Haloperidol

Products Haloperidol is commercially available as tablets, drops (Haldol), and as a solution for injection (Haldol, Haldol decanoas). It has been approved in many countries since 1960. Structure and properties Haloperidol (C21H23ClFNO2, Mr = 375.9 g/mol) is a derivative of pethidine, which is itself derived from atropine. It has structural similarity to loperamide. Haloperidol exists … Haloperidol

Trazodone

Products Trazodone is commercially available in the form of film-coated tablets and sustained-release tablets (Trittico, Trittico retard, Trittico Uno). The active ingredient was developed at Angelini in Italy in 1966 and has been approved in many countries since 1985. Auto-generics and generics are registered. Generic versions of the 100 mg film-coated tablets first went on … Trazodone

Tiapride

Products Tiapride is commercially available in tablet form (Tiapridal). It has been approved in many countries since 1981. Structure and properties Tiapride (C15H24N2O4S, Mr = 328.4 g/mol) is present in drugs as tiapride hydrochloride, a white crystalline powder that is very soluble in water. It is an orthomethoxy-substituted benzamide. Effects Tiapride (ATC N05AL03) has antidopaminergic … Tiapride