Products Domperidone is commercially available as film-coated tablets, lingual tablets, and as a suspension (Motilium, generics). It was synthesized in 1974 and has been approved in many countries since 1979. Structure and properties Domperidone (C22H24ClN5O2, Mr = 425.9 g/mol) exists as a white powder that is practically insoluble in water. It is a benzimidazole derivative … Domperidone
Effects Dopamine antagonists are antidopaminergic, antipsychotic, antiemetic, and prokinetic. They are antagonists at dopamine receptors, eg, dopamine (D2)-receptors, thus abolishing the effects of the neurotransmitter dopamine. Indications Psychotic disorders Nausea and vomiting, to promote gastric emptying and motility in the gastrointestinal tract. Some dopamine antagonists are also used to treat movement disorders (dyskinesias, including neuroleptic-induced), … Dopamine Antagonists
Products Medicines containing prochlorperazine are no longer registered in many countries, but other phenothiazines are available. Structure and properties Prochlorperazine (C20H24ClN3S, Mr = 373.9 g/mol) is present in drugs as prochlorperazine hydrogen maleate, a white to slightly yellowish crystalline powder that is very sparingly soluble in water. It is a chlorinated propylpiperazine derivative of phenothiazine. … Prochlorperazine
Products Chlorprothixene is commercially available in the form of film-coated tablets (Truxal). It has been approved in many countries since 1960. Distribution of the so-called Truxal 5 mg tablets was discontinued in many countries in 2011 for economic reasons. Structure and properties Chlorprothixene (C18H18ClNS, Mr = 315.9 g/mol) belongs to the thioxanthenes. It is present … Chlorprothixene
Products Tetrabenazine is commercially available in tablet form (Xenazine). It has been approved in many countries since 2008. Structure and properties Tetrabenazine (C19H27NO3, Mr = 317.4 g/mol) is a benzoquinolizine derivative. Effects Tetrabenazine (ATC N07XX06) has indirect antidopaminergic and transmitter depleting properties. It inhibits the uptake of dopamine, norepinephrine, and serotonin into the salivary vesicles … Tetrabenazine
Products Pimozide is no longer commercially available as a finished drug in many countries. It is still available in some countries (Orap tablets). Structure and properties Pimozide (C28H29F2N3O, Mr = 461.5 g/mol) belongs to the diphenylbutylpiperidines. It exists as a white powder that is practically insoluble in water. Effects Pimozide (ATC N05AG02) is antipsychotic. The … Pimozide
Products Pipamperone is commercially available in tablet form (dipiperone). It has been approved in many countries since 1964. Structure and properties Pipamperone (C21H30FN3O2, Mr = 375.5 g/mol) is present in drugs as pipamperondihydrochloride. It is structurally closely related to haloperidol, which also belongs to the butyrphenones. Butyrphenones, like numerous other active ingredients, originated in the … Pipamperon
Products Metoclopramide is commercially available in tablet, solution, and solution for injection (Primpéran, Paspertin). It has been approved in many countries since 1967. The drops and suppositories for children were withdrawn from the market in November 2011 because of the risk for extrapyramidal side effects. Structure and properties Metoclopramide (C14H22ClN3O2, Mr = 299.8 g/mol) is … Metoclopramide
