Netilmicin
Products Netilmicin is no longer available in many countries. Netromycin is out of commerce. Effects Netilmicin (ATC J01GB07) is bactericidal. Indications Bacterial infectious diseases
bactericidal
Lysozyme
Products Lysozyme is mainly commercialized in medicines for sore throat, e.g., Lysopain and Sangerol. Structure and properties Lysozyme is an endogenous mucopolysaccharidase (protein, enzyme) found in saliva and elsewhere. It is composed of 129 amino acids. Effects Lysozyme (ATC A01AB11) has bactericidal, antiviral, and anti-inflammatory properties. Indications Acute inflammatory conditions of the mouth and throat, … Lysozyme
Ofloxacin
Products Ofloxacin is commercially available as eye drops, eye ointment (Floxal, Floxal UD), tablets, and solution for injection (Tarivid). The active ingredient was approved in many countries in 1987, and the ophthalmic agents in 1992. The enantiomer levofloxacin is also on the market (Tavanic, generics). This article refers to ocular use. Structure and properties Ofloxacin … Ofloxacin
Beta Lactam Antibiotics against Bacterial Infections
Effect Beta-lactam antibiotics have bacteriostatic to bactericidal properties. They inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). PBPs include transpeptidases, which are responsible for cross-linking peptidoglycan chains during cell wall synthesis. Some beta-lactams can be degraded and thus inactivated by the bacterial enzyme beta-lactamase Indications The spectrum of beta-lactam antibiotics ranges from … Beta Lactam Antibiotics against Bacterial Infections
Moxifloxacin
Products Moxifloxacin is commercially available in the form of film-coated tablets, as an infusion solution, and eye drops (Avalox, Vigamox eye drops). It has been approved in many countries since 1999. Generic versions of the tablets went on sale in 2014. This article refers to oral administration; see also moxifloxacin eye drops. Structure and properties … Moxifloxacin
Moxifloxacin Eye Drops
Products Moxifloxacin eye drops have been approved in many countries since 2008 (Vigamox). Moxifloxacin is also available in tablet form and as an infusion solution; see Moxifloxacin. Generic versions of the eye drops are registered. Structure and properties Moxifloxacin (C21H24FN3O4, Mr = 401.4 g/mol) is present in the eye drops as moxifloxacin hydrochloride, a slightly … Moxifloxacin Eye Drops
Polihexanide
Products Polihexanide is commercially available as a solution and concentrate (Lavasept). It has been approved in many countries since 1991. Structure and properties Polihexanide (C8H19N5, Mr = 185.3 g/mol) is a biguanide derivative. Effects Polihexanide (ATC D08AC05) has bactericidal and fungicidal properties. Indications For antiseptic wound treatment and prophylaxis of bone and soft tissue infections. … Polihexanide
Daptomycin
Products Daptomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Cubicin). It has been approved in many countries since 2007. Generic versions are registered. Structure and properties Daptomycin (C72H101N17O26, Mr = 1620.7 g/mol) is a cyclic lipopeptide that is obtained as a fermentation product from . It … Daptomycin
Cloxacillin
Products Cloxacillin is commercially available as a veterinary drug in the form of injectables. Structure and properties Cloxacillin (Mr = 435.9 g/mol, C19H18ClN3O5S) is a derivative of 6-aminopenicillic acid. Effects Cloxacillin (ATCvet QJ51CF02) has bactericidal properties. Indications Prevention and treatment of udder infections in cows.
Carbapeneme
Effects Carbapenems (ATC J01DH) are bactericidal against aerobic and anaerobic Gram-positive and Gram-negative pathogens. Effects are based on binding to penicillin-binding proteins (PBP) and inhibition of bacterial cell wall synthesis, resulting in bacterial dissolution and death. Imipenem, the first representative of the drug group, is degraded by the renal enzyme dehydropeptidase-I (DHP-I). It is therefore … Carbapeneme
Ornidazole
Products Ornidazole is commercially available in the form of film-coated tablets and ampoules (Tiberal). It has been approved in many countries since 1980. Vaginal tablets for local treatment of trichomoniasis are out of commerce. Structure and properties Ornidazole (C7H10ClN3O3, Mr = 219.6 g/mol) is a nitroimidazole. Effects Ornidazole (ATC P01AB03, ATC J01XD03) has bactericidal and … Ornidazole
Oritavancin
Products Oritavancin was approved in the United States in 2014 as an infusion preparation (Orbactiv). The drug has not yet been registered in many countries. Structure and properties Oritavancin is present in drugs as oritavancin phosphate (C86H97N10O26Cl3 – 2H3PO4, Mr = 1989.1 g/mol) is present, a complex semisynthetically produced lipoglycopeptide structurally related to other glycopeptide … Oritavancin
