Products Zolmitriptan is commercially available as film-coated tablets, meltable tablets, and as a nasal spray (Zomig, generics). It has been approved in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Zolmitriptan (C16H21N3O2, Mr = 287.4 g/mol) is an indole and oxazolidinone derivative structurally related to serotonin. It exists as … Zolmitriptan
Definition Accumulation refers to the accumulation of an active pharmaceutical ingredient in the organism during regular drug administration. The term comes from the Latin (to accumulate). It occurs when there is an imbalance between the intake and elimination of the active ingredient. If the dosing interval is too short, too much drug is administered. If … Cumulation
Products Bisphosphonates are commercially available in the form of film-coated tablets and as injection and infusion preparations. They are also combined fixed with vitamin D3. Their effects on bone were described in the 1960s. Etidronate was the first active ingredient to be approved (out of trade). Structure and properties Bisphosphonates contain a central carbon atom … Bisphosphonates Effects and Side Effects
Products Estriol is commercially available in many countries as vaginal gel, vaginal cream, vaginal suppositories, vaginal tablets, and tablets for peroral therapy. This article refers to topical use. Structure and properties Estriol (C18H24O3, Mr = 288.4 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a natural metabolite of … Estriol
Products Damoctocog alfa pegol was approved as a preparation for solution for injection in the United States and the EU in 2018 and in many countries in 2019 (Jivi). Structure and properties Damoctocog alfa pegol is a pegylated, B-domain-deleted, conjugated, recombinant blood coagulation factor VIII (rFVIII). The molecular mass is approximately 234 kDa. The drug … Damoctocog Alfa Pegol
Definition and mechanisms A pharmacokinetic booster is an agent that improves the pharmacokinetic properties of another agent. It is a desirable drug interaction It can exert its effects at different levels (ADME): Absorption (uptake into the body). Distribution (distribution) Metabolism and first-pass metabolism (metabolization). Elimination (excretion) Pharmacokinetic enhancers can increase absorption, increase distribution to an … Pharmacokinetic Booster
Products Beta-blockers are available in many countries in the form of tablets, film-coated tablets, sustained-release tablets, as capsules, solution, eye drops, and as injection and infusion solutions. Propranolol (Inderal) was the first representative of this group to appear on the market in the mid-1960s. Today, the most important active ingredients include atenolol, bisoprolol, metoprolol and … Beta Blocker Effects and Side Effects
Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Definition So-called “creeping in” is a gradual increase in the dose of a drug over days or a few weeks. This is used to slowly accustom the patient to the drug and to test individual tolerability. Creeping in helps to avoid undesirable effects. The target dose may be predefined or determined individually. In the second … Gradual Increase of the Dose of a Drug
Products Transdermal patches are approved as medicinal products. They offer themselves as an alternative to other modes of application such as peroral and parenteral administration. The first products were launched in the 1970s. Structure and properties Transdermal patches are flexible pharmaceutical preparations of varying sizes and thinness that contain one or more active ingredients. They … Transdermal Patches
Introduction Elimination is a pharmacokinetic process that describes the irreversible removal of active pharmaceutical ingredients from the body. It is composed of biotransformation (metabolism) and excretion (elimination). The most important organs for excretion are the kidney and the liver. However, drugs can also be excreted through the respiratory tract, hair, saliva, milk, tears, and sweat. … Elimination
Products Capsaicin cream at 0.025% or 0.075% (also 0.1%) is not registered as a finished drug in many countries, unlike other countries. It is produced as an extemporaneous preparation in pharmacies. The specialized trade can also order them from specialized service providers. On the other hand, patches containing the active ingredient (Qutenza) are approved as … Capsaicin Cream
