Products Aducanumab has been studied in phase III trials and is in the pre-approval phase. The drug is not yet commercially available. The trials were discontinued in March 2019. However, following a re-analysis, the company announced in October 2019 that it expected to file for approval. Apparently, a sufficiently high dose is required for an … Aducanumab
Products Agalsidase is commercially available as an infusion preparation and has been approved in many countries since 2001 and 2003, respectively: Replagal: agalsidase alfa Fabrazyme: agalsidase beta Structure and properties Agalsidase is a recombinant human α-galactosidase A produced by biotechnological methods. The amino acid sequence is identical to the natural lysosomal enzyme. It is a … Agalsidase
Products Eyebright eye drops are available from various suppliers in vials and in the form of single doses. In addition to mono, combination preparations are also commercially available. Ingredients Eye drops contain a dilute or homeopathic preparation of eyebright herb (e.g. , , Scrophulariaceae). Effects Eyebright eye drops are believed to have soothing, moisturizing, anti-inflammatory, … Eyebright Eye Drops
Products Avibactam was approved in the United States in 2015, in the EU in 2016, and in many countries in 2019 in fixed combination with the cephalosporin ceftazidime as a powder for a concentrate for solution for infusion (Zavicefta). Structure and properties Avibactam (C7H11N3O6S, Mr = 265.25 g/mol), unlike other beta-lactamase inhibitors, is not itself … Avibactam
Products Oxymorphone is commercially available in the United States as tablets and sustained-release tablets and has also been administered parenterally and rectally. It is not registered in many countries. Oxymorphone has been approved in the U.S. since 1959 (brand names: Numorphan, Opana, Opana ER, generics). It is a narcotic drug. Due to the potential for … Oxymorphone
Products No ophthalmic ointments containing oxytetracycline are commercially available in many countries. In Germany, one preparation is available from Jenapharm. Structure and properties Oxytetracycline (C22H24N2O9, Mr = 460.4 g/mol) is present in the ointment as oxytetracycline hydrochloride, a yellow, crystalline, hygroscopic powder that is readily soluble in water. The substance is obtained from certain strains … Oxytetracycline Eye Ointment
Effects P2Y12 antagonists are antiplatelet agents and prevent the formation of blood clots. The effects are due to binding to the adenosine diphosphate receptor P2Y12 on platelets. This receptor plays a central role in glycoprotein (GP)-IIb/IIa activation and platelet aggregation. The continuous binding of adenosine diphosphate (ADP) to P2Y12 is an important prerequisite for thrombus … P2Y12 Antagonists
Products Delavirdin is commercially available in the United States under the brand name Rescriptor. It is not commercially available in many countries. Structure and properties Delavirdine (C22H28N6O3S, Mr = 456.6 g/mol) Effects Delavirdine (ATC J05AG02) is antiviral and an inhibitor of HIV reverse transcriptase. Indications HIV
Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
