Products Zidovudine is commercially available as film-coated tablets, capsules, and syrup (Retrovir AZT, combination products). It was approved in 1987 as the first AIDS drug. Structure and properties Zidovudine (C10H13N5O4, Mr = 267.2 g/mol) or 3-azido-3-deoxythymidine (AZT) is an analog of thymidine. It exists as an odorless, white to beige, crystalline substance that is soluble … Zidovudine (AZT)
Products Stavudine is commercially available in capsule form (Zerit). It has been approved in many countries since 1996. Structure and properties Stavudine (C10H12N2O4, Mr = 224.2 g/mol) is a thymidine analog with a missing 3′-hydroxy group. It is a prodrug that is biotransformed intracellularly to the active metabolite stavudine triphosphate. Stavudine exists as a white … Stavudine
Products Cortisone tablets are medicinal products which are intended for ingestion and contain active substances from the group of glucocorticoids. The tablets, water-soluble tablets and sustained-release tablets are usually monopreparations, which are often divisible. Glucocorticoids were first used medicinally in the late 1940s. Structure and properties The glucocorticoids contained in the drugs are derived from … Cortisone Tablets Effects and Side Effects
Products 5α-Reductase inhibitors are commercially available in many countries in the form of film-coated tablets and capsules. Finasteride was the first agent from this group to be approved in 1993 (USA: 1992). There are two finasteride drugs on the market. One with 5 mg for the treatment of prostate enlargement (Proscar, generic) and one with … 5Α-Reductase Inhibitors
Products Sofosbuvir is commercially available in the form of film-coated tablets (Sovaldi). It was approved in the United States and EU in 2013 and in many countries in 2014. The very high price of the drug has been a source of debate. Sofosbuvir is also combined fixed with ledipasvir (Harvoni). Cheaper generics are available in … Sofosbuvir
Products Crisaborole was approved in the United States in 2016 as an ointment (Eucrisa, 2%). Crisaborole is not currently registered in many countries. Structure and properties Crisaborole (C14H10BNO3, Mr = 251.0 g/mol) is a low molecular weight boron compound with a nonsteroidal structure. It belongs to the phenoxybenzoxaboroles. Due to its small size, the compound … Crisaborol
Effects Glucocorticoids (ATC R03BA02) have anti-inflammatory, antiallergic, and immunosuppressive properties. The effects are based on binding to intracellular receptors, resulting in an influence on protein expression. In addition, glucocorticoids also exert extragenomic effects. All agents are lipophilic (virtually insoluble in water) and thus enter cells well across the cell membrane. Indications For the treatment of … Inhaled Glucocorticoids
Products Prednisolone commercially available as an eye drop suspension (Pred forte). Structure and properties Prednisolone is present in the drug in the form of the ester prednisolone acetate (C23H30O6, Mr = 402.5 g/mol). Prednisolone acetate is a prodrug that is hydrolyzed in the body to the active metabolite prednisolone. Effects Prednisolone acetate (ATC S01BA04) has … Prednisolone Eye Drops
Products Gemcitabine is commercially available as a lyophilizate for the preparation of an infusion solution (Gemzar, generics). It has been approved in many countries since 1997. Structure and properties Gemcitabine (C9H11F2N3O4, Mr = 263.2 g/mol) is present in drugs as gemcitabine hydrochloride, a white substance that is soluble in water. The pyrimidine gemcitabine is a … Gemcitabine
Products Hydrocortisone acetate eye ointment Hydrocortisone-POS 1% was approved in many countries in 2014. Structure and properties Hydrocortisone acetate (C23H32O6, Mr = 404.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is an acetylated hydrocortisone (cortisol). Effects Hydrocortisone acetate (ATC S01BA02) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. The … Hydrocortisone Acetate Eye Ointment
Products Hydrocortisone butyrate is commercially available as emulsion and cream (Locoid). It has been approved in many countries since 1973. Structure and properties Hydrocortisone-17-butyrate (C25H36O6, Mr = 432.6 g/mol) is an esterified, nonhalogenated glucocorticoid. It is a derivative of endogenous hydrocortisone. Effects Hydrocortisone butyrate (ATC D07AB02) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. The effects … Hydrocortisone Butyrate
Products Emtricitabine is commercially available as a monopreparation in the form of capsules and as an oral solution (Emtriva, combination products, generics). It has been approved in many countries since 2004. Structure and properties Emtricitabine (C8H10FN3O3S, Mr = 247.2 g/mol) is a thioanalog of cytidine with a fluorine atom at the 5-position. It exists as … Emtricitabine
