Products Copper is commercially available in multivitamin preparations, dietary supplements, and ointments and solutions, among other products. Hormone-free intrauterine devices (known as “coils”) or copper chains are also approved for contraception. These are medical devices and not drugs. Structure and properties Copper (cuprum, Cu, atomic number 29) is a soft and easily workable transition and … Copper
Products The fixed combination Deanxit with the two active ingredients melitracene and flupentixol is commercially available in many countries in the form of film-coated tablets. The drug has been approved since 1973, initially as dragées. The marketing authorization holder is the Danish company Lundbeck. Structure and properties The active ingredients are present in the drug … Melitracene and Flupentixol
Products Sofosbuvir is commercially available in the form of film-coated tablets (Sovaldi). It was approved in the United States and EU in 2013 and in many countries in 2014. The very high price of the drug has been a source of debate. Sofosbuvir is also combined fixed with ledipasvir (Harvoni). Cheaper generics are available in … Sofosbuvir
Products Carteolol is available in the form of extended-release eye drops (Arteoptic LA). Carteolol has been approved in many countries since 1984. Arteopilo, the combination with pilocarpine, is no longer marketed in many countries. Structure and properties Carteolol (C16H24N2O3, Mr = 292.4 g/mol) is a dihydroquinolinone and a racemate. It is present in drugs as … Carteolol
Products Octocog alfa is commercially available as an injectable. It has been approved in many countries since 2004. Structure and properties Octocog alfa is the recombinant blood clotting factor VIII produced by biotechnological methods. In the past, it was also obtained from plasma, but this posed a risk for the transmission of infectious diseases. Octocog … Octocog Alfa
Products Valaciclovir is commercially available in the form of film-coated tablets (Valtrex, generic). It has been approved in many countries since 1995. Structure and properties Valaciclovir (C13H20N6O4, Mr = 324.3 g/mol) is the ester of the natural amino acid valine and the antiviral drug aciclovir. It is present in drugs as valaciclovir hydrochloride, a white … Valaciclovir
Products Alfacalcidol is commercially available in Germany in the form of soft capsules, drops, and as a solution for injection (e.g., EinsAlpha). It is not registered in many countries. Structure and properties Alfacalcidol (C27H44O2, Mr = 400.6 g/mol) corresponds to 1-hydroxycholecalciferol. It is in the form of white crystals and is practically insoluble in water. … Alfacalcidol
Effects Carbapenems (ATC J01DH) are bactericidal against aerobic and anaerobic Gram-positive and Gram-negative pathogens. Effects are based on binding to penicillin-binding proteins (PBP) and inhibition of bacterial cell wall synthesis, resulting in bacterial dissolution and death. Imipenem, the first representative of the drug group, is degraded by the renal enzyme dehydropeptidase-I (DHP-I). It is therefore … Carbapeneme
Products Enalapril is commercially available in tablet form (Reniten, generics). It has been approved in many countries since 1984. The active ingredient is also combined fixed with hydrochlorothiazide. Structure and properties Enalapril (C20H28N2O5, 376.45 g/mol) is present in drugs as enalapril maleate, a white powder that is sparingly soluble in water. Enalapril is the prodrug … Enalapril: Drug Effects, Side Effects, Dosage and Uses
Products Repaglinide is commercially available in tablet form (NovoNorm, generic). It was approved in many countries in 1999. Structure and properties Repaglinide (C27H36N2O4, Mr = 452.6 g/mol) is a meglitinide and carbamoylmethylbenzoic acid derivative without sulfonylurea structure. It is a white, odorless powder that is practically insoluble in water due to its lipophilicity. In drugs, … Repaglinide
Products Peforelin is commercially available as a solution for injection for animals. It has been approved in many countries since 2009. Structure and properties Peforelin is a synthetic analog of gonadotropin-releasing hormone (GnRH) in which four amino acids have been exchanged. Effects Peforelin (ATCvet QH01CA) selectively stimulates the release of FSH and promotes follicular growth, … Peforelin
Products Naftazone is commercially available in the form of film-coated tablets (Mediaven, Mediaven forte). It has been approved in many countries since 1973. Structure and properties Naftazone (C11H9N3O, Mr = 215.21 g/mol) Effects Naftazone (ATC C05B) increases venous tone and inhibits iysosomal enzymes in the vein wall. Indications All forms of venous insufficiency Diabetic retinopathy … Naftazone
