Products Numerous nasal sprays containing vasoconstrictive agents are commercially available. Among the best known are xylometazoline (Otrivin, generic) and oxymetazoline (Nasivin). In addition to sprays, nasal drops and nasal gels are also available. Decongestants for the nose have been available since the early 20th century (Sneader, 2005). As early as the 1940s, rhinitis medicamentosa was … Decongestant Nasal Sprays
Symptoms Rhinitis medicamentosa manifests as a stuffy nose with swollen and histologically altered nasal mucosa. Causes It is the result of prolonged use of decongestant nasal medications (sprays, drops, oils, gels) containing active ingredients such as xylometazoline, oxymetazoline, naphazoline, or phenylephrine. Because the nasal mucosa no longer swells on its own and habituation occurs, the … Rhinitis Medicamentosa
Symptoms Pain in the ear (technical term: otalgia) can be unilateral or bilateral and persistent or intermittent. They vary in intensity and nature, can be extremely uncomfortable, and sometimes go away on their own. Ear pain is often accompanied by other symptoms, such as a discharge from the ear canal, difficulty hearing, a feeling of … Earache Causes and Treatment
Products Sympathomimetics are commercially available, for example, in the form of tablets, capsules, granules, injectable solutions, eye drops, and nasal sprays. Structure and properties Sympathomimetics are structurally derived from the natural neurotransmitters epinephrine and norepinephrine. Effects Sympathomimetics have sympathomimetic properties, meaning that they promote the effects of the sympathetic nervous system, a portion of the … Sympathomimetics
Capsules Phenylpropanolamine Paracetamol Dextrometorphan Available as Pretuval tablets. Wick DayMed cold drink Phenylephrine Paracetamol Ascorbic acid Guaifenesin Available as Pretuval effervescent tablets.
Products Dimetinden maleate is commercially available as drops, gel, lotion, nasal spray, and nasal drops (Fenistil, Feniallerg, Vibrocil, Otriduo). The nasal products also contain the vasoconstrictor phenylephrine. The Fenistil products used internally (systemically) were renamed Feniallerg in 2009. The capsules and dragées are no longer available. Structure and properties Dimetind (C20H24N2, Mr = 292.4 g/mol) … Dimetindenmaleate
Symptoms Vasomotor rhinitis manifests as a chronic watery-running and/or stuffy nose. Symptoms resemble hay fever but occur year-round and without eye involvement. Both diseases can also occur together. Other possible symptoms include sneezing, itching, headache, frequent swallowing and coughing. Causes and triggers Vasomotor rhinitis is one of the nonallergic and noninfectious rhinitides. The exact causes … Vasomotor Rhinitis
Products Nasal sprays are very widely used and there are many different products on the market, which are approved drugs or medical devices (see below). Nasal sprays are also manufactured in pharmacies. Structure and properties Nasal sprays are solutions, emulsions, or suspensions intended for spraying into the nasal cavities. They may contain one or more … Nasal Sprays
Effects Antihistamine nasal sprays have antihistamine and antiallergic properties. They are antagonists of histamine at the H1 receptor, reversing histamine effects and thus relieving symptoms such as sneezing, itching, and runny nose. Azelastine is also mast cell stabilizing, which is considered a therapeutic advantage. Glucocorticoid nasal sprays are more effective than antihistamine nasal sprays, but … Antihistamine Nasal Sprays
Products Stimulants are commercially available as drugs, narcotics, dietary supplements, and foods. Dosage forms include tablets, capsules, and solutions. Structure and properties Stimulants do not have a uniform chemical structure, but groups can be identified. Many, for example the amphetamines, are derived from the natural catecholamines such as epinephrine and norepinephrine. Effects The active ingredients … Stimulants
Anatomical background Humans have 4 sinuses, the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses. They are connected to the nasal cavity by 1-3 mm narrow bony openings called ostia and are lined with a thin respiratory epithelium with goblet cells and seromucous glands. The ciliated hairs provide clearance of mucus … Acute Sinusitis
Definition Drugs today usually contain a defined active pharmaceutical ingredient. However, numerous drugs with two or more active substances also exist. These are called combination drugs or fixed combinations. For example, Aspirin C contains both acetylsalicylic acid and vitamin C. Many blood pressure medications are combination preparations, for example perindopril + indapamide or candesartan + … Combination Products
