Products Azathioprine is commercially available as film-coated tablets and as a lyophilizate (Imurek, generic). It has been approved in many countries since 1965. Structure and properties Azathioprine (C9H7N7O2S, Mr = 277.3 g/mol) is a nitromidazole derivative of mercaptopurine. It exists as a pale yellow powder that is practically insoluble in water. Effects Azathioprine (ATC L04AX01) … Azathioprine (Imuran)
Products Rituximab is commercially available as a concentrate for the preparation of an infusion solution and as a solution for subcutaneous injection (MabThera, MabThera subcutaneous). It has been approved in many countries and in the United States since 1997 and in the EU since 1998. Biosimilars are available in some countries, including many (2018, Rixathon, … Rituximab
Products Infliximab is commercially available as a powder for a concentrate for the preparation of an infusion solution (Remicade, biosimilars: Remsima, Inflectra). It has been approved in many countries since 1999. Biosimilars were released in 2015. Structure and properties Infliximab is a chimeric human murine IgG1κ monoclonal antibody with a molecular mass of 149.1 kDa … Infliximab: Drug Effects, Side Effects, Dosage and Uses
Products Aceclofenac is approved in Germany, among other countries, in the form of film-coated tablets (Beofenac). It is not registered in many countries. Structure and properties Aceclofenac (C16H13Cl2NO4, Mr = 354.2 g/mol) is structurally related to diclofenac and is partially metabolized to it. It exists as a white crystalline powder that is practically insoluble in … Aceclofenac
Rheumatism is a collective term for all pain and inflammatory diseases of the locomotor system, with partial effects on other systems of our body. Among other things joints, tendons and ligaments, muscles and bones can be affected. The causes are manifold, from autoimmune diseases, metabolic disorders to degeneration (wear and tear in old age). Autoimmune … Physiotherapy for rheumatic diseases
Products Cortisone tablets are medicinal products which are intended for ingestion and contain active substances from the group of glucocorticoids. The tablets, water-soluble tablets and sustained-release tablets are usually monopreparations, which are often divisible. Glucocorticoids were first used medicinally in the late 1940s. Structure and properties The glucocorticoids contained in the drugs are derived from … Cortisone Tablets Effects and Side Effects
Products Benoxaprofen was commercially available in tablet form (Oraflex, Opren) beginning in 1980. It was withdrawn from the market again in August 1982 because of the numerous adverse effects reported. Structure and properties Benoxaprofen (C16H12ClNO3, Mr = 301.7 g/mol) is a chlorinated benzoxazole derivative and exists as a racemate. It belongs to the propionic acid … Benoxaprofen
Products Sulfasalazine is commercially available as tablets and as dragées with an enteric coating (salazopyrin, salazopyrin EN, some countries: azulfidine, azulfidine EN, or RA). It has been approved in many countries since 1950. EN stands for enteric coated and RA for Rheumatoid Arthritis. EN dragées have a coating to prevent irritation and improve gastric tolerance. … Sulfasalazine: Drug Effects, Side Effects, Dosage and Uses
Symptoms Rheumatoid arthritis is a chronic, inflammatory and systemic joint disease. It manifests as pain, symmetrically tense, achy, warm, and swollen joints, swelling, and morning stiffness that lasts for more than an hour. Initially, the hands, wrists, and feet are most affected, but later numerous other joints are also affected. Over time, deformities and rheumatoid … Rheumatoid Arthritis Causes and Treatment
Products Abatacept is commercially available as an injection and infusion preparation (Orencia). It was approved in the United States in 2005 and in the EU and many countries in 2007. Structure and properties Abatacept is a recombinant fusion protein with the following components: Extracellular domain of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Modified Fc domain of … Abatacept
Symptoms The two leading symptoms of Sjögren’s syndrome (pronounced “Schögren”) are dry mouth and dry eyes with associated symptoms such as conjunctivitis, difficulty swallowing and speaking, gingivitis, and tooth decay. The nose, throat, skin, lips and vagina are also frequently dry. In addition, many other organs may be affected less frequently and include muscle and … Sjögren’s Syndrome: Causes and Treatment
Products Cyclophosphamide is commercially available in the form of dragées and as a dry substance for intravenous infusion (Endoxan). It has been approved in many countries since 1960. Structure and properties Cyclophosphamide (C7H15Cl2N2O2P, Mr = 261.1 g/mol) is a cytostatic drug belonging to the group of oxazaphosphorines, nitrogen-lost derivative. Effects Cyclophosphamide (ATC L01AA01) has cytotoxic … Cyclophosphamide