Amoxicillin (Amoxil)

Products Amoxicillin is commercially available in the form of tablets, film-coated tablets, dispersible tablets, as powder or granules for the preparation of a suspension, as an infusion and injection preparation, and as a veterinary drug. In addition to the original Clamoxyl, numerous generics are available today. Amoxicillin was launched in 1972 and has been approved … Amoxicillin (Amoxil)

Ampicillin (Polycillin, Principen, Omnipen)

Products In many countries, human drugs containing ampicillin are no longer commercially available. In other countries, film-coated tablets and injectables are available, often in fixed combination with sulbactam. Structure and properties Ampicillin (C16H19N3O4S, Mr = 349.4 g/mol) exists as a white crystalline powder that is sparingly soluble in water. In contrast, the sodium salt ampicillin … Ampicillin (Polycillin, Principen, Omnipen)

Fusidic Acid

Products Fusidic acid is commercially available as film-coated tablets, cream, ointment, gauze, and ophthalmic drip gel (including Fucidin, Fucithalmic, and generics). It has been approved in many countries since 1968. See also under fusidic acid eye gel. Structure and properties Fusidic acid (C31H48O6, Mr = 516.7 g/mol) belongs to the steroid antibiotics. It is obtained … Fusidic Acid

Carmellose

Products Carmellose is commercially available in the form of eye drops and as an oral spray (e.g., Cellufluid, Glandosane, Optava). Structure and properties Carmellose is the calcium or sodium salt of a partially -carboxymethylated cellulose (carboxymethylcellulose calcium or carboxymethylcellulose sodium). Effects Carmellose (ATC S01XA20) forms an optically clear film on the eye, which approximates natural … Carmellose

Thiomersal

Products Thiomerasal has been used as an excipient in pharmaceuticals, especially in liquid dosage forms such as eye drops and vaccines. It is rarely used today because of the potential adverse effects. The substance is also known as thimerosal. Structure and properties Thiomerasal (C9H9HgNaO2S, Mr = 404.8 g/mol) exists as a white crystalline powder and … Thiomersal

Sodium Sulfite

Products Sodium sulfite is used as an excipient in pharmaceuticals. It is also used for food and cosmetics. Structure and properties Pharmacopoeially monographed sodium sulfite heptahydrate (Na2SO3 – 7 H2O, Mr = 252.2 g/mol) exists as colorless crystals and is readily soluble in water. It can be prepared with, for example, sulfur dioxide and sodium … Sodium Sulfite

Pantoprazole

Products Pantoprazole is commercially available in the form of enteric-coated tablets and has been approved in many countries since 1997 (Pantozol, generic). Less commonly used are the granules and the injectable. Structure and properties Pantoprazole (C16H15F2N3O4S, Mr = 383.37 g/mol) is a benzimidazole derivative and a racemate. In tablets, it is present as sodium salt … Pantoprazole

Active Ingredient Salts

Structure and properties Many active pharmaceutical ingredients are present in the drug as organic salts. This means that the active ingredient is ionized and its charge is neutralized by a counterion (English ). For example, naproxen is present in the over-the-counter pain reliever as a sodium salt. In this form, it is referred to as … Active Ingredient Salts

Pentobarbital

Products Pentobarbital is no longer commercially available as a finished drug for human use in many countries. Legally, it belongs to narcotics (schedule b) and is available only by prescription. Pharmacies can order the powder from specialized suppliers. Structure and properties Pentobarbital (C11H18N2O3, Mr = 226.3 g/mol) exists as a white crystalline powder or as … Pentobarbital

Phenobarbital

Products Phenobarbital is commercially available in tablet form and as a solution for injection (aphenylbarbit, phenobarbital Bichsel). It was approved in many countries in 1944. Luminal has been off the market in many countries since late August 2011. Barbexaclone (maliasin), a fixed combination of phenobarbital and L-propylhexedrine, is also no longer available. Structure and properties … Phenobarbital

Glutamate

Products Glutamate is present in many foods, “convenience foods,” spices, sauces, and broths as a food additive (e.g., E 621). It can be obtained chemically-synthetically, hydrolytically or by fermentation. “Hidden” glutamate, some of which is undeclared, can be found in yeast extract and hydrolyzed vegetable protein, for example. Structure and properties Glutamate is usually referred … Glutamate

Piperacillin

Products Piperacillin is commercially available as an injectable (tazobac + tazobactam, generics). It has been approved in many countries since 1992. Structure and properties Piperacillin (C23H27N5O7S, Mr = 517.6 g/mol) is present in drugs as piperacillin sodium, a white crystalline powder that is readily soluble in water. Tazobactam (C10H12N4O5S, Mr = 300.3 g/mol) also exists … Piperacillin