Products Irbesartan is commercially available in the form of film-coated tablets as a monopreparation (Aprovel, generic) and as a fixed combination with hydrochlorothiazide (Co-Aprovel). It has been approved in many countries since 1997. Generics entered the market in many countries in August 2012. Generic versions of the combination preprinted with hydrochlorothiazide went on sale in … Irbesartan
Symptoms Possible symptoms of clinically manifest magnesium deficiency include: Neuromuscular symptoms such as a tremor, muscle spasms, fasciculations (involuntary muscle movements), seizures Central disorders: Apathy, fatigue, dizziness, delirium, coma. Cardiovascular disorders: ECG changes, cardiac arrhythmias, palpable heartbeats, hypertension. Osteoporosis, Altered glucose homeostasis. Magnesium deficiency is often accompanied by calcium and potassium deficiency. However, many patients … Magnesium Deficiency
Products Doping agents include approved drugs, legal and illegal intoxicants, experimental agents, and illegally manufactured and trafficked substances. Doping includes non-drug doping methods, such as blood doping, in addition to drugs. Effects Doping agents differ in their pharmacological activities. Stimulants, for example, stimulate and thus increase alertness and aggressiveness for competition. In contrast, beta-blockers provide … Doping in Competitive Sports
Products Chlortalidone is commercially available in tablet form (combination products). It has been approved in many countries since 1967. This article refers to the monopreparations. Hygroton (Novartis) was discontinued in many countries in 2014. Structure and properties Chlortalidone (C14H11ClN2O4S, Mr = 338.77 g/mol) is a racemate. It exists as a white to yellowish white powder … Chlortalidone
Synonyms in a broader sense water tablets, dehydration drugs, furosemide, thiazides Definition Diuretics are a group of drugs that lead to increased urinary excretion (diuresis). They are often referred to as “water tablets” kidneys, because they increase the excretion of fluids over the They are used in the treatment of high blood pressure, to flush … Diuretics
Different groups of drugs Three different groups (substance classes) of diuretics are given to promote water excretion: In the following, the different types of diuretics are presented in more detail and their specific mode of action and side effects are described Loop diuretics Thiazides Potassium saving diuretics In the treatment of high blood pressure, this … Different groups of drugs | Diuretics
Side effects Every drug has side effects – this is also the case with diuretics.The different groups of diuretics also have a different side effect profile, but some side effects are found in all drugs. In general, each drug carries the risk of developing hypersensitivity or allergy. This can lead to skin rashes, discomfort and … Side effects | Diuretics
What should be considered when weaning? A diuretic is a dehydrating drug that can be given for various diseases. Some of these diseases are serious and the use of the diuretic is well-considered by your doctor, so it is not recommended to discontinue a diuretic independently without consultation. For example, in the case of a … What should be considered when weaning? | Diuretics
Products Metolazone is commercially available in tablet form as a generic product (Metolazone Galepharm). The original Zaroxolyn is no longer available. Structure and properties Metolazone (C16H16ClN3O3S, Mr = 365.8 g/mol) is a quinazoline sulfonamide that is sparingly soluble in water. It is structurally related to the thiazides. Effects Metolazone (ATC C03BA08) has diuretic and thiazide-like … Metolazone
Products Indapamide is commercially available as tablets and capsules alone in sustained-release formulations (Fludex SR, generic) and in combination with the ACE inhibitor perindopril (Coversum N Combi, generic). A fixed combination of perindopril, indapamide, and amlodipine is also available (Coveram plus). Indapamide was developed in the 1970s and has been approved in many countries since … Indapamide
Products Benzthiazide is no longer commercially available in many countries. It was formerly included in combination with triamterene in Dyrenium compositum. Structure and properties Benzthiazide (C15H14ClN3O4S3, Mr = 431.9 g/mol) Effects Benzthiazide has diuretic properties. Indications Edema Arterial hypertension
Products Butizide was marketed exclusively in combination with spironolactone in the form of film-coated tablets (Aldozone). It had been approved in many countries since 1968. Structure and properties Buticide (C11H16ClN3O4S2, Mr = 353.8 g/mol) Effects Buticide (ATC C03EA14) has diuretic properties. Indications In combination with spironolactone: Heart failure Liver cirrhosis with ascites and/or edema. Nephrotic … Buticide
