Renal Cell Carcinoma or Hypernephroma

Renal Cell Carcinoma (Hypernephroma): Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body temperature, body weight, body height; furthermore: Inspection (viewing) of the skin and mucous membranes. Inspection and palpation (palpation) Lymph node stations (cervical, axillary, supraclavicular, inguinal). Spine Mammae (mammary glands) [due topossible paraneoplastic symptoms: Galactorrhea … Renal Cell Carcinoma (Hypernephroma): Examination

Renal Cell Carcinoma (Hypernephroma): Test and Diagnosis

Laboratory parameters of 1st order – obligatory laboratory tests. Small blood count (Hb value, platelet count). Differential blood count (neutrophil count). Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate). Urine status (rapid test for: Nitrite, protein, hemoglobin, erythrocytes, leukocytes, urobilinogen) incl. sediment, if necessary urine culture (pathogen detection and resistogram, that is, … Renal Cell Carcinoma (Hypernephroma): Test and Diagnosis

Renal Cell Carcinoma (Hypernephroma): Drug Therapy

Therapeutic target Prolonging survival in metastatic renal cell carcinoma (RCC). Therapy recommendations Therapy procedure of first choice is surgery. In metastatic clear cell renal cell carcinoma (approximately 75-80% of cases): first-line therapy for metastatic renal cell carcinoma (mNCC) should be risk-adapted [S3 guideline]Criteria for this are: 6 International Metastatic RCC Database Consortium (IMDC) criteria: Anemia … Renal Cell Carcinoma (Hypernephroma): Drug Therapy

Renal Cell Carcinoma (Hypernephroma): Diagnostic Tests

Mandatory medical device diagnostics. Sonography (ultrasonography) of the abdomen or renal ultrasonography – as a basic diagnostic test. [Renal tumors can be detected from about 5 mm; T1a: tumor 4 cm or less in greatest extent; 5-7% of all renal cell carcinomas are completely cystic; 4-15% of all solid renal cell carcinomas have cystic portions] … Renal Cell Carcinoma (Hypernephroma): Diagnostic Tests

Renal Cell Carcinoma (Hypernephroma): Surgical Therapy

Active Surveillance (“Active Waiting”). There are neither objective criteria for selecting adequate patients nor a uniform definition for active surveillance. In patients with high comorbidity (serious concomitant diseases) and/or limited life expectancy, the small renal tumor (diameter ≤ 4 cm) can be monitored.In old age, tumors grow very slowly and tend not to metastasize. In … Renal Cell Carcinoma (Hypernephroma): Surgical Therapy

Renal Cell Carcinoma (Hypernephroma): Prevention

To prevent hypernephroma (renal cell carcinoma), attention must be paid to reducing individual risk factors. Behavioral risk factors Consumption of stimulants Tobacco (smoking) Overweight (BMI ≥ 25; obesity). Environmental pollution – intoxications (poisonings). Arsenic Men: mortality risk (risk of death)/relative risk (RR) 1.75 (95 percent confidence interval 1.49-2.05). Women: Mortality risk/relative risk 2.09 (95-percent confidence … Renal Cell Carcinoma (Hypernephroma): Prevention

Renal Cell Carcinoma (Hypernephroma): Radiotherapy

Because renal cell carcinoma (hypernephroma) has very little radiation sensitivity, radiation therapy (radiotherapy) is used only in advanced stages of the disease to treat metastases (daughter tumors). This therapy serves exclusively to alleviate symptoms. Further notes Stereotactic ablative radiotherapy (SABR): method in which high-energy radiation (e.g., photons) is used to destroy tumor tissue with high … Renal Cell Carcinoma (Hypernephroma): Radiotherapy

Renal Cell Carcinoma (Hypernephroma): Symptoms, Complaints, Signs

Hypernephroma (renal cell carcinoma) usually does not cause early symptoms. The following symptoms and complaints may indicate advanced hypernephroma: Painless hematuria or painless macrohematuria – blood in the urine or visible blood in the urine (because of tumor invasion of the renal pelvis; common initial symptom and also a late symptom). Anemia (anemia) Anorexia (loss … Renal Cell Carcinoma (Hypernephroma): Symptoms, Complaints, Signs

Renal Cell Carcinoma (Hypernephroma): Causes

Pathogenesis (disease development) Renal cell carcinoma usually involves chromosome 3p deletions (genetic alterations). This causes an amplification of several factors that promote tumor growth. These factors include VEGF (vascular endothelial growth factor) and PDGF (platelet-derived growth factor). Etiology (Causes) Biographic Causes Genetic burden from parents, grandparents (about 3%). Genetic diseases Birt-Hogg-Dubé syndrome (BHDS) – genetic … Renal Cell Carcinoma (Hypernephroma): Causes

Renal Cell Carcinoma (Hypernephroma): Therapy

General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Aim for or maintain normal weight! Determination of BMI (body mass index, body mass index) or body composition by means of electrical impedance analysis. BMI ≥ 25 → participation in … Renal Cell Carcinoma (Hypernephroma): Therapy

Renal Cell Carcinoma (Hypernephroma): Or something else? Differential Diagnosis

Infectious and parasitic diseases (A00-B99). Tuberculosis (consumption). Neoplasms – tumor diseases (C00-D48) Benign (benign) neoplasms in the area of the kidney such as adenomas. Adrenal tumors, unspecified. Renal pelvic carcinoma (renal pelvic cancer) and other malignant neoplasms of the kidney, such as sarcomas or lymphomas Renal metastases Wilms tumor (nephroblastoma) – malignant (malignant), embryonal, relatively … Renal Cell Carcinoma (Hypernephroma): Or something else? Differential Diagnosis

Renal Cell Carcinoma (Hypernephroma): Complications

The following are the most important diseases or complications that can be caused by hypernephroma (renal cell carcinoma): Neoplasms – Tumor Diseases (C00-D48). Malignant melanoma (primary melanoma) (3.19 times the standardized incidence rate as the ratio of observed to expected tumor incidence) Metastases (daughter tumors). Brain Bone Liver Lung (first filter station) (60-70%) Note: Primary … Renal Cell Carcinoma (Hypernephroma): Complications