The main active ingredient of Musaril® is tetrazepam, which belongs to the benzodiazepine group and acts on muscle reflection. Through this action, Musaril® reduces abnormal muscle tension, arousal (panic attacks), anxiety and promotes sleep. In addition, tetrazepam can be used to treat epilepsy. The active ingredient may no longer be prescribed as of August 1, 2013, because a comprehensive study by the European Commission showed that some patients treated with tetrazepam suffered severe skin reactions that were life-threatening or even fatal. These skin reactions were not predictable and could occur at any time during the therapy.
Mode of action
In the human nervous system there are various neurotransmitters (messenger substances) that can have an inhibitory or activating effect. Normally, these messengers are present in a state of equilibrium and thus enable an appropriate reaction to external circumstances such as stress or rest. Tetrazepam now enhances the effect of the messenger GABA, which has an inhibitory effect on the nervous system as soon as it docks to a receptor. Through this mechanism of action, tetrazepam can cause muscle relaxation and sedation.
Effect onset and duration
The active ingredient tetrazepam is completely absorbed in the intestines and the effect of tetrazepam can last for several days. Similarly, the substances that are produced after metabolism by the liver are still effective. Musaril® with the active ingredient tetrazepam was used by the European Commission before it was banned by the European Commission: Tetrazepam was used in the form of tablets and drops.
The dosage of tetrazepam was 50mg/day at the beginning of the therapy and was slowly increased up to 200mg/day. In cases of impaired kidney function, in children, adolescents and older patients, the dosage had to be adapted to the individual metabolic situation. Dose changes had to be made in both directions, each time gradually, i.e. step by step over a period of several weeks.
- Pathological muscle tension due to pain
- Panic Attacks
- Anxiety disorders
- Spastic nervous system diseases (Morbus Little, Multiple Sclerosis)
